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    Cd82 Cd82 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83628, updated on 24-Apr-2024

    Summary

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    Official Symbol
    Cd82provided by RGD
    Official Full Name
    Cd82 moleculeprovided by RGD
    Primary source
    RGD:69070
    See related
    Ensembl:ENSRNOG00000000047 AllianceGenome:RGD:69070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kai1
    Summary
    Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Biomarker of hypertension and ovarian cancer. Orthologous to human CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 424.5), Kidney (RPKM 309.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd82 in Genome Data Viewer
    Location:
    3q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (99842748..99887298, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79387361..79431847, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82324344..82368846, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101602 Neighboring gene uncharacterized LOC134486408 Neighboring gene ALX homeobox 4 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene uncharacterized LOC120101603

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination. Mela A, et al. J Neurosci, 2009 Sep 9. PMID 19741124, Free PMC Article
    2. Protein networking in bladder cancer: immunoreactivity for FGFR3, EGFR, ERBB2, KAI1, PTEN, and RAS in normal and malignant urothelium. Røtterud R, et al. Histol Histopathol, 2007 Apr. PMID 17290345
    3. [Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance]. Xiong Y, et al. Ai Zheng, 2005 Jan. PMID 15642213
    4. Temporal changes in gene expression after injury in the rat retina. Vázquez-Chona F, et al. Invest Ophthalmol Vis Sci, 2004 Aug. PMID 15277499, Free PMC Article
    5. Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression. Jackson P, et al. Prostate Cancer Prostatic Dis, 2003. PMID 12806379

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD82 appears to be a critical molecule in the regulation of oligodendrocyte progenitor migration and myelination.
      Title: The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD82 antigen
    Names
    CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
    Kangai 1 (suppression of tumerigenicity 6 prostate) CD82 antigen
    Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
    kangai 1 (suppression of tumorigenicity 6), prostate
    metastasis suppressor Kangai-1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429482.1 → NP_001416411.1  CD82 antigen

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    2. NM_001429483.1 → NP_001416412.1  CD82 antigen

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_031797.2 → NP_113985.2  CD82 antigen

      See identical proteins and their annotated locations for NP_113985.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072498
      UniProtKB/Swiss-Prot
      O70352
      UniProtKB/TrEMBL
      A0A8I5ZZR7, A6HNI9, F7EV99, Q6IN14
      Related
      ENSRNOP00000084636.1, ENSRNOT00000100406.1
      Conserved Domains (2) summary
      cd03160
      Location:106 → 228
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:24 → 255
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      99842748..99887298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234598.3 → XP_006234660.1  CD82 antigen isoform X1

      UniProtKB/Swiss-Prot
      O70352
      UniProtKB/TrEMBL
      A0A8I5ZZR7, A6HNI9, F7EV99, Q6IN14
      Conserved Domains (2) summary
      cd03160
      Location:106 → 228
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:24 → 255
      Tetraspannin; Tetraspanin family

    2. XM_006234597.5 → XP_006234659.1  CD82 antigen isoform X1

      UniProtKB/Swiss-Prot
      O70352
      UniProtKB/TrEMBL
      A0A8I5ZZR7, A6HNI9, F7EV99, Q6IN14
      Related
      ENSRNOP00000000052.5
      Conserved Domains (2) summary
      cd03160
      Location:106 → 228
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:24 → 255
      Tetraspannin; Tetraspanin family

    3. XM_039105948.2 → XP_038961876.1  CD82 antigen isoform X2

      UniProtKB/TrEMBL
      A6HNJ0
      Conserved Domains (1) summary
      cd03160
      Location:40 → 162
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    4. XM_039105951.2 → XP_038961879.1  CD82 antigen isoform X3

      Conserved Domains (1) summary
      cd03160
      Location:1 → 112
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    5. XM_039105953.2 → XP_038961881.1  CD82 antigen isoform X3

      Conserved Domains (1) summary
      cd03160
      Location:1 → 112
      CD37_CD82_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70352.1 GenPept UniProtKB/Swiss-Prot:O70352

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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