Vkorc1l1 vitamin K epoxide reductase complex, subunit 1-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Vkorc1l1provided by RGD
Full Name: vitamin K epoxide reductase complex, subunit 1-like 1provided by RGD
Primary source: RGD:1303249
See related: AllianceGenome:RGD:1303249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 114.6), Brain (RPKM 106.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12-q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32354078..32404327, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26717959..26768193, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30218825..30268990, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
molecular cloning
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:489243 (e-PCR)
- UniSTS:489243

RH142529 (e-PCR)
- UniSTS:231776

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables quinone binding	IEA Inferred from Electronic Annotation more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA Inferred from Direct Assay more info	PubMed
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IEA Inferred from Electronic Annotation more info
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-glutamic acid carboxylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info
involved_in vitamin K metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin K metabolic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: vitamin K epoxide reductase complex subunit 1-like protein 1

Names: VKORC1-like protein 1

NP_976083.1

EC 1.17.4.4

XP_017453907.2

EC 1.17.4.4

XP_038945585.2

EC 1.17.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_203338.1 → NP_976083.1 vitamin K epoxide reductase complex subunit 1-like protein 1

See identical proteins and their annotated locations for NP_976083.1

Status: VALIDATED

Source sequence(s)

AY423048

UniProtKB/Swiss-Prot

Q6TEK3

Conserved Domains (1) summary

cd12917
Location:18 → 156

VKOR_euk; Vitamin K epoxide reductase family in eukaryotes, excluding plants

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

32354078..32404327 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598418.3 → XP_017453907.2 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZWM1
XM_039089657.2 → XP_038945585.2 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1