Zfp263 zinc finger protein 263 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp263provided by RGD
Official Full Name: zinc finger protein 263provided by RGD
Primary source: RGD:1307301
See related: Ensembl:ENSRNOG00000007678 AllianceGenome:RGD:1307301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription, DNA-templated. Predicted to be located in nucleus. Orthologous to human ZNF263 (zinc finger protein 263). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 52.6), Thymus (RPKM 45.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (12270785..12280982, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11764424..11774324, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (12023677..12035189, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138844 (e-PCR)
- UniSTS:220931

AI326880 (e-PCR)
- UniSTS:160516

PMC196232P1 (e-PCR)
- UniSTS:271803

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 263

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399418.1 → NP_001386347.1 zinc finger protein 263

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZQ68

Related

ENSRNOP00000010442.6, ENSRNOT00000010442.7

Conserved Domains (5) summary

smart00431
Location:41 → 151

SCAN; leucine rich region

COG5048
Location:460 → 646

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:436 → 456

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:645 → 667

zf-H2C2_2; Zinc-finger double domain

cl02581
Location:219 → 257

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

12270785..12280982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245831.5 → XP_006245893.1 zinc finger protein 263 isoform X1

UniProtKB/TrEMBL

A6K4V1

Conserved Domains (7) summary

cd07765
Location:134 → 172

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

smart00349
Location:135 → 193

KRAB; krueppel associated box

COG5048
Location:375 → 561

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:351 → 371

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:349 → 371

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:41 → 127

SCAN; SCAN domain

pfam13465
Location:391 → 416

zf-H2C2_2; Zinc-finger double domain
XM_063268528.1 → XP_063124598.1 zinc finger protein 263 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001105763.1: Suppressed sequence

Description

NM_001105763.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.