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    Cpa3 carboxypeptidase A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54242, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cpa3provided by RGD
    Official Full Name
    carboxypeptidase A3provided by RGD
    Primary source
    RGD:2390
    See related
    Ensembl:ENSRNOG00000011181 AllianceGenome:RGD:2390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of angiotensin levels in blood. Predicted to be located in transport vesicle. Predicted to be active in extracellular space. Orthologous to human CPA3 (carboxypeptidase A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 82.7), Thymus (RPKM 45.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpa3 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (104641619..104673253, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (102712483..102744219, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (105016798..105047989, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glycogenin 1 Neighboring gene eukaryotic translation initiation factor 4 gamma 1, pseudogene 1 Neighboring gene carboxypeptidase B1 Neighboring gene angiotensin II receptor, type 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning. Xing D, et al. J Surg Res, 2014 Nov. PMID 24953986
    2. Rat mast cell carboxypeptidase: amino acid sequence and evidence of enzyme activity within mast cell granules. Cole KR, et al. Biochemistry, 1991 Jan 22. PMID 1988052
    3. The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain. Kayashima T, et al. Hum Genet, 2003 Mar. PMID 12552318
    4. Human mast cell carboxypeptidase. Purification and characterization. Goldstein SM, et al. J Clin Invest, 1989 May. PMID 2708524, Free PMC Article
    5. Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II. Lundequist A, et al. J Biol Chem, 2004 Jul 30. PMID 15173164

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data suggest that ischemic preconditioning protected against reperfusion injury via the mast cell degranulation-mediated release of MC-CPA.
      Title: Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of angiotensin levels in blood IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of angiotensin levels in blood ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mast cell carboxypeptidase A
    Names
    R-CPA
    RMC-CP
    carboxypeptidase A3, mast cell
    NP_062173.1
    XP_038958908.1
    XP_038958909.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019300.1 → NP_062173.1  mast cell carboxypeptidase A precursor

      See identical proteins and their annotated locations for NP_062173.1

      Status: VALIDATED

      Source sequence(s)
      FM101110, U67914
      UniProtKB/Swiss-Prot
      P21961, P97597
      UniProtKB/TrEMBL
      A6IHD2, F1M7S4
      Related
      ENSRNOP00000014970.8, ENSRNOT00000014970.8
      Conserved Domains (2) summary
      pfam02244
      Location:28 → 102
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:114 → 413
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      104641619..104673253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102980.2 → XP_038958908.1  mast cell carboxypeptidase A isoform X1

      UniProtKB/Swiss-Prot
      P21961, P97597
      UniProtKB/TrEMBL
      A0A8I6GL18
      Related
      ENSRNOP00000095188.1
      Conserved Domains (2) summary
      pfam02244
      Location:32 → 103
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:114 → 379
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

    2. XM_039102981.2 → XP_038958909.1  mast cell carboxypeptidase A isoform X2

      Conserved Domains (2) summary
      pfam02244
      Location:32 → 103
      Propep_M14; Carboxypeptidase activation peptide
      cl11393
      Location:114 → 327
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21961.2 GenPept UniProtKB/Swiss-Prot:P21961

    Gene LinkOut

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