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    Onecut2 one cut homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307376, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Onecut2provided by RGD
    Official Full Name
    one cut homeobox 2provided by RGD
    Primary source
    RGD:1564677
    See related
    Ensembl:ENSRNOG00000052665 AllianceGenome:RGD:1564677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564677
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including liver development; negative regulation of transforming growth factor beta receptor signaling pathway; and peripheral nervous system neuron development. Predicted to be located in actin cytoskeleton and nucleoplasm. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 167.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Onecut2 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (60101967..60161095)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (57831647..57890884)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (59830375..59882490)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene uncharacterized LOC102553013 Neighboring gene RGD1562699 Neighboring gene ferrochelatase Neighboring gene asparaginyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene. Jacquemin P, et al. Biochem Biophys Res Commun, 2001 Aug 3. PMID 11478782
    2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. Vanhorenbeeck V, et al. Biochem Biophys Res Commun, 2002 Apr 12. PMID 11944891
    3. The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Margagliotti S, et al. Dev Biol, 2007 Nov 15. PMID 17936262
    4. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Clotman F, et al. Genes Dev, 2005 Aug 15. PMID 16103213, Free PMC Article
    5. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Pierreux CE, et al. Gastroenterology, 2006 Feb. PMID 16472605

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peripheral nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    one cut domain family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400633.1 → NP_001387562.1  one cut domain family member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2KA21
      Related
      ENSRNOP00000075225.2, ENSRNOT00000078378.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      60101967..60161095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097412.2 → XP_038953340.1  one cut domain family member 2 isoform X1

      Conserved Domains (1) summary
      pfam02376
      Location:332 → 404
      CUT; CUT domain
    Nucleotide Protein Strain
    Heading Accession and Version

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