S100a9 S100 calcium binding protein A9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a9provided by RGD
Official Full Name: S100 calcium binding protein A9provided by RGD
Primary source: RGD:620267
See related: AllianceGenome:RGD:620267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mrp14
Summary: Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in several processes, including autocrine signaling; response to ethanol; and response to lipopolysaccharide. Located in extracellular space. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A9 (S100 calcium binding protein A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 1142.0), Lung (RPKM 417.5) and 2 other tissues See more
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178487941..178490622, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (176190361..176193182, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (190097436..190100209, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Surprising Nonlinear Effects of S100A9 Proteins in the Retina.
Title: The Surprising Nonlinear Effects of S100A9 Proteins in the Retina.
Transcriptomic Analysis of Retinal Gene in Experimental Retinal Detachment Rats and Exploration of S100A9 and TLR4 in Human Vitreous.
Title: Transcriptomic Analysis of Retinal Gene in Experimental Retinal Detachment Rats and Exploration of S100A9 and TLR4 in Human Vitreous.
Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription.
Title: Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription.
Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model.
Title: Transcriptome analysis of the effect of diosgenin on autoimmune thyroiditis in a rat model.
MRP8/14 was associated with abdominal aortic aneurysm presence and progression.
Title: Myeloid related protein 8/14 is a new candidate biomarker and therapeutic target for abdominal aortic aneurysm.
these results suggest that calprotectin, along with other inflammatory factors, promotes the inflammation seen in mild food allergy
Title: Upregulation of calprotectin in mild IgE-mediated ovalbumin hypersensitivity.
Recombinant rat r-S100A9 bound to r-CD68. The expression levels of S100A9 were significantly suppressed after the macrophages had been treated with an anti-CD68 antibody. Small interfering CD68 also significantly suppressed activation of macrophages through an autocrine pathway by r-S100A9.
Title: CD68 on rat macrophages binds tightly to S100A8 and S100A9 and helps to regulate the cells' immune functions.
In dextran sulfate sodium-induced colitis fecal levels of S100A9 detected by ELISA were significantly elevated before microscopic damage was detected.
Title: Enzyme-linked immunosorbent assay for S100A9 in the stool of rats with dextran sulfate sodium-induced colitis.
Decreased S100A9 expression promoted airway smooth muscle cell proliferation by stimulating reactive oxygen species generation and inhibiting p38 MAPK.
Title: Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK.
Expression of S100A9 mRNA and the corresponding protein in cultured NRVCs was similar between control cells and NE-stimulated cells, but was markedly upregulated at 12 hours after the withdrawal of NE
Title: Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9.

Submit: New GeneRIF Correction See all GeneRIFs (17)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in autocrine signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in autocrine signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in chronic inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in chronic inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte migration involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation of process of another organism	IEA Inferred from Electronic Annotation more info
involved_in neutrophil aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil aggregation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil aggregation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-cysteine S-nitrosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of integrin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of integrin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of S100A9 complex	IEA Inferred from Electronic Annotation more info
part_of S100A9 complex	ISO Inferred from Sequence Orthology more info
part_of calprotectin complex	IEA Inferred from Electronic Annotation more info
part_of calprotectin complex	ISO Inferred from Sequence Orthology more info
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A9

Names: MRP-14; S100 calcium binding protein A9 (calgranulin B); calgranulin-B; intracellular calcium-binding protein (MRP14); migration inhibitory factor-related protein 14; myeloid-related protein 14; p14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053587.2 → NP_446039.2 protein S100-A9

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P50116, Q761U7

UniProtKB/TrEMBL

A0A0H2UHJ1, A6J6Q4

Conserved Domains (1) summary

cd05030
Location:7 → 95

calgranulins; Calgranulins: S-100 domain found in proteins belonging to the Calgranulin subgroup of the S100 family of EF-hand calcium-modulated proteins, including S100A8, S100A9, and S100A12 . Note that the S-100 hierarchy, to which this Calgranulin group belongs, ...