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    Synpr synaptoporin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66030, updated on 2-May-2024

    Summary

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    Official Symbol
    Synprprovided by RGD
    Official Full Name
    synaptoporinprovided by RGD
    Primary source
    RGD:708366
    See related
    Ensembl:ENSRNOG00000008203 AllianceGenome:RGD:708366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Is integral component of synaptic vesicle membrane. Orthologous to human SYNPR (synaptoporin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 382.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Synpr in Genome Data Viewer
    Location:
    15p16-p15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (14003861..14330808, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (11573373..11900255, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (14558613..14885790, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sentan, cilia apical structure protein Neighboring gene ribosomal protein S20, pseudogene 5 Neighboring gene uncharacterized LOC102552767 Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene calcium dependent secretion activator Neighboring gene Histone deacetylase 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mossy fiber-CA3 synapses mediate homeostatic plasticity in mature hippocampal neurons. Lee KJ, et al. Neuron, 2013 Jan 9. PMID 23312519, Free PMC Article
    2. Synaptoporin, a novel putative channel protein of synaptic vesicles. Knaus P, et al. Neuron, 1990 Oct. PMID 2206533
    3. Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein. Dai J, et al. Mol Biol Rep, 2003 Sep. PMID 12974474
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptoporin
    Names
    synaptorin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023974.1 → NP_076464.1  synaptoporin precursor

      See identical proteins and their annotated locations for NP_076464.1

      Status: PROVISIONAL

      Source sequence(s)
      AF306459
      UniProtKB/Swiss-Prot
      P22831, Q9ERH1
      UniProtKB/TrEMBL
      A0A0G2K1H2, A6K083
      Related
      ENSRNOP00000011307.3, ENSRNOT00000011307.6
      Conserved Domains (1) summary
      pfam01284
      Location:69 → 196
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      14003861..14330808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093644.2 → XP_038949572.1  synaptoporin isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1H2, A0A8I5ZK40, A6K082
      Related
      ENSRNOP00000076574.1
      Conserved Domains (1) summary
      pfam01284
      Location:15 → 216
      MARVEL; Membrane-associating domain

    2. XM_063274618.1 → XP_063130688.1  synaptoporin isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22831.2 GenPept UniProtKB/Swiss-Prot:P22831

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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