Sh2d1a SH2 domain containing 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh2d1aprovided by RGD
Official Full Name: SH2 domain containing 1Aprovided by RGD
Primary source: RGD:1562408
See related: AllianceGenome:RGD:1562408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562408
Summary: Predicted to be involved in negative regulation of T cell receptor signaling pathway. Predicted to act upstream of or within humoral immune response and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 1. Orthologous to human SH2D1A (SH2 domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 381.6), Spleen (RPKM 89.8) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: Xq35

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (126239191..126267425)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (121373693..121401923)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (128897053..128925408)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAP may serve as a negative regulator of Trk receptor activation and downstream signaling
Title: SLAM-associated protein as a potential negative regulator in Trk signaling.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

DXGot56 (e-PCR)
- UniSTS:113573

RH129944 (e-PCR)
- UniSTS:213232

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: SH2 domain-containing protein 1A

Names: SH2 domain protein 1A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109313.2 → NP_001102783.2 SH2 domain-containing protein 1A

See identical proteins and their annotated locations for NP_001102783.2

Status: PROVISIONAL

Source sequence(s)

BC167036

UniProtKB/Swiss-Prot

B2RZ59

Conserved Domains (1) summary

cd10400
Location:2 → 104

SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a