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    Nfam1 Nfat activating molecule with ITAM motif 1 [ Mus musculus (house mouse) ]

    Gene ID: 74039, updated on 9-May-2024

    Summary

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    Official Symbol
    Nfam1provided by MGI
    Official Full Name
    Nfat activating molecule with ITAM motif 1provided by MGI
    Primary source
    MGI:MGI:1921289
    See related
    Ensembl:ENSMUSG00000058099 AllianceGenome:MGI:1921289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cnaip; 4921501M20Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in B cell differentiation and positive regulation of B cell receptor signaling pathway. Acts upstream of or within B cell receptor signaling pathway and regulation of B cell differentiation. Located in cell surface and membrane raft. Orthologous to human NFAM1 (NFAT activating protein with ITAM motif 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 12.2), mammary gland adult (RPKM 6.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfam1 in Genome Data Viewer
    Location:
    15 E1; 15 39.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82880937..82917598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82996736..83033397, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene transcription factor 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82805127-82805236 Neighboring gene microRNA 3080 Neighboring gene STARR-positive B cell enhancer mm9_chr15:82818187-82818488 Neighboring gene expressed sequence AW121686 Neighboring gene STARR-positive B cell enhancer ABC_E7401 Neighboring gene STARR-positive B cell enhancer ABC_E3149 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:82873210-82873393 Neighboring gene STARR-seq mESC enhancer starr_39309 Neighboring gene predicted gene, 32620 Neighboring gene STARR-positive B cell enhancer ABC_E3150 Neighboring gene predicted gene, 41366 Neighboring gene STARR-positive B cell enhancer ABC_E7402 Neighboring gene serine hydrolase-like Neighboring gene ribosomal RNA processing 7 homolog A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes. Juchem KW, et al. Front Immunol, 2021. PMID 35095847, Free PMC Article
    2. Calcineurin/nuclear factors of activated T cells (NFAT)-activating and immunoreceptor tyrosine-based activation motif (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway. Yang J, et al. J Biol Chem, 2003 May 9. PMID 12615919
    3. Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1. Zhu J, et al. Oxid Med Cell Longev, 2022. PMID 35615580, Free PMC Article
    4. NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Ohtsuka M, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15143214, Free PMC Article
    5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
      Title: Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
    2. NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development
      Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NFAT activation molecule 1
    Names
    calcineurin/NFAT-activating ITAM-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271411.1 → NP_001258340.1  NFAT activation molecule 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001258340.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC133880, AK150635
      Consensus CDS
      CCDS70652.1
      UniProtKB/Swiss-Prot
      Q3UAX8, Q8R4V1, Q9D5Z3
      UniProtKB/TrEMBL
      Q3TBS2, Q3TD63
      Related
      ENSMUSP00000154945.2, ENSMUST00000231165.2

    2. NM_001271412.1 → NP_001258341.1  NFAT activation molecule 1 isoform b

      See identical proteins and their annotated locations for NP_001258341.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC133880, AK150635
      UniProtKB/TrEMBL
      Q3TC65, Q3TCT5

    3. NM_001271413.1 → NP_001258342.1  NFAT activation molecule 1 isoform c

      See identical proteins and their annotated locations for NP_001258342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AK048992
      Consensus CDS
      CCDS70651.1
      UniProtKB/TrEMBL
      A7E2R9
      Related
      ENSMUSP00000023076.6, ENSMUST00000023076.6

    4. NM_001271414.1 → NP_001258343.1  NFAT activation molecule 1 isoform c

      See identical proteins and their annotated locations for NP_001258343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AC129563, AK014802, AK048992
      Consensus CDS
      CCDS70651.1
      UniProtKB/TrEMBL
      A7E2R9

    5. NM_028728.3 → NP_083004.1  NFAT activation molecule 1 isoform d

      See identical proteins and their annotated locations for NP_083004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC129563, AK014802
      Consensus CDS
      CCDS27694.1
      UniProtKB/TrEMBL
      A7E2R9
      Related
      ENSMUSP00000105129.4, ENSMUST00000109503.10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82880937..82917598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4V1.1 GenPept UniProtKB/Swiss-Prot:Q8R4V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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