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    Pygb brain glycogen phosphorylase [ Mus musculus (house mouse) ]

    Gene ID: 110078, updated on 12-May-2024

    Summary

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    Official Symbol
    Pygbprovided by MGI
    Official Full Name
    brain glycogen phosphorylaseprovided by MGI
    Primary source
    MGI:MGI:97828
    See related
    Ensembl:ENSMUSG00000033059 AllianceGenome:MGI:97828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including glycogen phosphorylase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Predicted to be involved in glycogen catabolic process. Predicted to be located in axon. Predicted to be active in cytoplasm. Is expressed in alimentary system; nervous system; sensory organ; and urinary system. Orthologous to human PYGB (glycogen phosphorylase B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 143.6), bladder adult (RPKM 120.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pygb in Genome Data Viewer
    Location:
    2 G3; 2 74.74 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150628716..150673668)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150786796..150831748)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2053 Neighboring gene STARR-positive B cell enhancer ABC_E1604 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 6 Neighboring gene predicted gene, 30141 Neighboring gene STARR-positive B cell enhancer ABC_E11166 Neighboring gene predicted gene, 57834 Neighboring gene STARR-seq mESC enhancer starr_06017 Neighboring gene abhydrolase domain containing 12 Neighboring gene predicted gene, 23598 Neighboring gene predicted gene, 54124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke. Cai Y, et al. iScience, 2020 May 22. PMID 32446205, Free PMC Article
    2. Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes. Müller MS, et al. Glia, 2015 Jan. PMID 25130497
    3. Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2). Nanda N, et al. Arch Biochem Biophys, 1999 Jun 1. PMID 10334875
    4. The pituitary hormones arginine vasopressin-neurophysin II and oxytocin-neurophysin I show close linkage with interleukin-1 on mouse chromosome 2. Marini JC, et al. Genomics, 1993 Jan. PMID 8432536
    5. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Glaser T, et al. Genomics, 1989 Oct. PMID 2575583

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36329

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SHG alpha-glucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogen phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogen phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linear malto-oligosaccharide phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycogen phosphorylase, brain form
    NP_722476.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153781.1 → NP_722476.1  glycogen phosphorylase, brain form

      See identical proteins and their annotated locations for NP_722476.1

      Status: PROVISIONAL

      Source sequence(s)
      BC035283
      Consensus CDS
      CCDS16862.1
      UniProtKB/Swiss-Prot
      Q8CI94, Q8K283
      UniProtKB/TrEMBL
      Q3TFQ8, Q3UGT5, Q3UYH9, Q3V3U0
      Related
      ENSMUSP00000035743.8, ENSMUST00000045441.8
      Conserved Domains (2) summary
      cd04300
      Location:29 → 828
      GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
      TIGR02093
      Location:32 → 828
      P_ylase; glycogen/starch/alpha-glucan phosphorylases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150628716..150673668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CI94.3 GenPept UniProtKB/Swiss-Prot:Q8CI94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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