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    Anapc1 anaphase promoting complex subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 17222, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Anapc1provided by MGI
    Official Full Name
    anaphase promoting complex subunit 1provided by MGI
    Primary source
    MGI:MGI:103097
    See related
    Ensembl:ENSMUSG00000014355 AllianceGenome:MGI:103097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apc1; Mcpr; tsg24; 2610021O03Rik
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein K11-linked ubiquitination. Predicted to act upstream of or within cell division. Located in nucleus. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.6), limb E14.5 (RPKM 12.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anapc1 in Genome Data Viewer
    Location:
    2 F1; 2 62.63 cM
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128452003..128529558, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128610083..128687406, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene predicted gene, 39929 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4498 Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene transmembrane protein 87B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel murine gene encoding a 216-kDa protein is related to a mitotic checkpoint regulator previously identified in Aspergillus nidulans. Starborg M, et al. J Biol Chem, 1994 Sep 30. PMID 7929068
    2. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Davis ES, et al. Genetics, 2002 Feb. PMID 11861581, Free PMC Article
    3. Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex. Jörgensen PM, et al. Gene, 2001 Jan 10. PMID 11179667
    4. The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition. Sun J, et al. Mol Cell Biol, 2013 Mar. PMID 23263983, Free PMC Article
    5. The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Cao J, et al. Sci Signal, 2015 Sep 1. PMID 26329581

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma.
      Title: The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.
    2. EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact.
      Title: The phosphatase-transcription activator EYA1 is targeted by anaphase-promoting complex/Cdh1 for degradation at M-to-G1 transition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 1
    Names
    cyclosome subunit 1
    meiotic check point regulator
    mitotic checkpoint regulator
    testis-specific gene 24 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008569.2 → NP_032595.2  anaphase-promoting complex subunit 1

      See identical proteins and their annotated locations for NP_032595.2

      Status: VALIDATED

      Source sequence(s)
      AK034858, AK077847, BB676785, BC139002, BE987509
      Consensus CDS
      CCDS16715.1
      UniProtKB/Swiss-Prot
      A2ATQ4, P53995, Q8BP33, Q8C772
      UniProtKB/TrEMBL
      B7ZNX2
      Related
      ENSMUSP00000014499.4, ENSMUST00000014499.10
      Conserved Domains (2) summary
      pfam01851
      Location:1467 → 1501
      PC_rep; Proteasome/cyclosome repeat
      pfam12859
      Location:150 → 218
      ANAPC1; Anaphase-promoting complex subunit 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128452003..128529558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248086.2 → XP_030103946.1  anaphase-promoting complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      B7ZNX2
      Conserved Domains (2) summary
      pfam01851
      Location:1349 → 1383
      PC_rep; Proteasome/cyclosome repeat
      pfam18122
      Location:1618 → 1777
      APC1_C; Anaphase-promoting complex sub unit 1 C-terminal domain

    2. XM_011239332.4 → XP_011237634.1  anaphase-promoting complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A2ATQ5
      Related
      ENSMUSP00000105962.2, ENSMUST00000110333.2
      Conserved Domains (1) summary
      pfam12859
      Location:150 → 218
      ANAPC1; Anaphase-promoting complex subunit 1

    RNA

    1. XR_004938638.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53995.2 GenPept UniProtKB/Swiss-Prot:P53995

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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