Ckap5 cytoskeleton associated protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ckap5provided by MGI
Official Full Name: cytoskeleton associated protein 5provided by MGI
Primary source: MGI:MGI:1923036
See related: Ensembl:ENSMUSG00000040549 AllianceGenome:MGI:1923036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0097; 3110043H24Rik; 4930432B04Rik; D730027C18Rik
Summary: Predicted to enable microtubule binding activity; microtubule plus end polymerase; and ribonucleoprotein complex binding activity. Acts upstream of or within several processes, including central nervous system myelin formation; dendritic spine maintenance; and learning. Located in dendrite; neuronal ribonucleoprotein granule; and perikaryon. Is expressed in several structures, including nervous system; nose; respiratory system; thymus primordium; and tooth. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 33.2), CNS E14 (RPKM 22.3) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E1; 2 50.63 cM

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (91357092..91451024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (91526747..91620679)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
Title: Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice.
our results demonstrate that CKAP5 is important in oocyte maturation and early embryo development, and CKAP5 might work together with CLTC in mouse oocyte maturation
Title: Cytoskeleton-associated protein 5 and clathrin heavy chain binding regulates spindle assembly in mouse oocytes.
in hippocampal neurons TOG is required for granule assembly, granule translation and synaptic plasticity, and affects behavior
Title: Conditional knockout of tumor overexpressed gene in mouse neurons affects RNA granule assembly, granule translation, LTP and short term habituation.
Aurora-A kinase does not regulate TACC3-chTOG complex formation, indicating that Aurora-A solely functions as a recruitment factor for the TACC3-chTOG complex to centrosomes and proximal mitotic spindles.
Title: The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
ch-TOG promotes axonal development and is expressed in brain throughout development.
Title: Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125283 (e-PCR)
- UniSTS:162105

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus end polymerase	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system myelin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cytoplasmic translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytoplasmic translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habituation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein-RNA complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein-RNA complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in neuronal ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytoskeleton-associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165989.2 → NP_001159461.1 cytoskeleton-associated protein 5 isoform 1

See identical proteins and their annotated locations for NP_001159461.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL691489

Consensus CDS

CCDS50640.1

UniProtKB/Swiss-Prot

A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0

UniProtKB/TrEMBL

K3W4R5

Related

ENSMUSP00000106970.4, ENSMUST00000111338.10

Conserved Domains (1) summary

pfam12348
Location:856 → 1048

CLASP_N; CLASP N terminal
NM_029437.2 → NP_083713.2 cytoskeleton-associated protein 5 isoform 2

See identical proteins and their annotated locations for NP_083713.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BC089032, BC096422

Consensus CDS

CCDS16433.1

UniProtKB/Swiss-Prot

A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0

UniProtKB/TrEMBL

A0A0R4J0K2

Related

ENSMUSP00000046263.10, ENSMUST00000046769.16

Conserved Domains (1) summary

pfam12348
Location:856 → 1048

CLASP_N; CLASP N terminal