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    Atp9b ATPase, class II, type 9B [ Mus musculus (house mouse) ]

    Gene ID: 50771, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Atp9bprovided by MGI
    Official Full Name
    ATPase, class II, type 9Bprovided by MGI
    Primary source
    MGI:MGI:1354757
    See related
    Ensembl:ENSMUSG00000024566 AllianceGenome:MGI:1354757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IIb; MMR; Atpc2b
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Is expressed in several structures, including adrenal gland; alimentary system; liver; nervous system; and thymus. Orthologous to human ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 29.2), thymus adult (RPKM 16.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp9b in Genome Data Viewer
    Location:
    18 E3; 18 53.9 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80777356..80977291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80734141..80934081, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41790 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Neighboring gene predicted gene, 52342 Neighboring gene STARR-positive B cell enhancer mm9_chr18:80888627-80888928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:80935003-80935320 Neighboring gene STARR-seq mESC enhancer starr_45180 Neighboring gene STARR-positive B cell enhancer ABC_E7617 Neighboring gene STARR-seq mESC enhancer starr_45183 Neighboring gene spalt like transcription factor 3 Neighboring gene predicted gene 27239

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel receptor on allograft (H-2d)-induced macrophage (H-2b) toward an allogeneic major histocompatibility complex class I molecule, H-2Dd, in mice. Tashiro-Yamaji J, et al. Microbiol Immunol, 2006. PMID 16490928
    2. Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer. Tosti E, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35688320, Free PMC Article
    3. Highly conserved non-coding sequences and the 18q critical region for short stature: a common mechanism of disease? Rizzolio F, et al. PLoS One, 2008 Jan 23. PMID 18213369, Free PMC Article
    4. The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease. Paulusma CC, et al. Biochim Biophys Acta, 2005 Jun 30. PMID 15919184
    5. Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis. Schauwecker PE, et al. J Comp Neurol, 2004 Sep 6. PMID 15281082

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.
      Title: Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IIB
    Names
    ATPase 9B, class II
    ATPase 9B, p type
    ATPase, class 2, member b
    macrophage MHC receptor
    NP_001188498.1
    NP_056620.2
    XP_006526569.1
    XP_006526570.1
    XP_030106388.1
    XP_030106389.1
    XP_030106390.1
    XP_030106391.1
    XP_030106392.1
    XP_030106393.1
    XP_030106394.1
    XP_036017094.1
    XP_036017096.1
    XP_036017097.1
    XP_036017098.1
    XP_036017099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201569.1 → NP_001188498.1  probable phospholipid-transporting ATPase IIB isoform 1

      See identical proteins and their annotated locations for NP_001188498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK166562, BC079626
      Consensus CDS
      CCDS89288.1
      UniProtKB/Swiss-Prot
      P98195, Q68FM3, Q99LI3
      UniProtKB/TrEMBL
      D3YV00
      Related
      ENSMUSP00000089394.5, ENSMUST00000091790.5
      Conserved Domains (6) summary
      TIGR01652
      Location:130 → 1144
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:187 → 425
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:577 → 659
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:123 → 180
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:899 → 1138
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:866 → 894
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_015805.3 → NP_056620.2  probable phospholipid-transporting ATPase IIB isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK030485, AK166562, BC079626
      Consensus CDS
      CCDS29370.1
      UniProtKB/Swiss-Prot
      P98195, Q68FM3, Q99LI3
      UniProtKB/TrEMBL
      A0A286YCV0
      Related
      ENSMUSP00000153157.2, ENSMUST00000225980.2
      Conserved Domains (1) summary
      cd07541
      Location:131 → 1055
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      80777356..80977291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526507.4 → XP_006526570.1  probable phospholipid-transporting ATPase IIB isoform X2

      UniProtKB/Swiss-Prot
      P98195, Q68FM3, Q99LI3
      Conserved Domains (2) summary
      cd07541
      Location:131 → 1076
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:596 → 680
      Cation_ATPase; Cation transport ATPase (P-type)

    2. XM_006526506.4 → XP_006526569.1  probable phospholipid-transporting ATPase IIB isoform X1

      UniProtKB/Swiss-Prot
      P98195, Q68FM3, Q99LI3
      Conserved Domains (2) summary
      cd07541
      Location:131 → 1076
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:596 → 680
      Cation_ATPase; Cation transport ATPase (P-type)

    3. XM_036161201.1 → XP_036017094.1  probable phospholipid-transporting ATPase IIB isoform X4

      Conserved Domains (2) summary
      cd07541
      Location:1 → 807
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:300 → 411
      Cation_ATPase; Cation transport ATPase (P-type)

    4. XM_030250528.2 → XP_030106388.1  probable phospholipid-transporting ATPase IIB isoform X3

      Conserved Domains (2) summary
      cd07541
      Location:11 → 825
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:345 → 429
      Cation_ATPase; Cation transport ATPase (P-type)

    5. XM_030250532.2 → XP_030106392.1  probable phospholipid-transporting ATPase IIB isoform X5

      Conserved Domains (2) summary
      pfam13246
      Location:216 → 300
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 696
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. XM_030250534.2 → XP_030106394.1  probable phospholipid-transporting ATPase IIB isoform X6

      Conserved Domains (2) summary
      pfam13246
      Location:155 → 266
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 662
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. XM_030250531.2 → XP_030106391.1  probable phospholipid-transporting ATPase IIB isoform X5

      Conserved Domains (2) summary
      pfam13246
      Location:216 → 300
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 696
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    8. XM_030250533.1 → XP_030106393.1  probable phospholipid-transporting ATPase IIB isoform X6

      Conserved Domains (2) summary
      pfam13246
      Location:155 → 266
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 662
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    9. XM_030250529.2 → XP_030106389.1  probable phospholipid-transporting ATPase IIB isoform X4

      Conserved Domains (2) summary
      cd07541
      Location:1 → 807
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:300 → 411
      Cation_ATPase; Cation transport ATPase (P-type)

    10. XM_030250530.1 → XP_030106390.1  probable phospholipid-transporting ATPase IIB isoform X5

      Conserved Domains (2) summary
      pfam13246
      Location:216 → 300
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 696
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    11. XM_036161203.1 → XP_036017096.1  probable phospholipid-transporting ATPase IIB isoform X6

      Conserved Domains (2) summary
      pfam13246
      Location:155 → 266
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 662
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    12. XM_036161205.1 → XP_036017098.1  probable phospholipid-transporting ATPase IIB isoform X7

      Conserved Domains (2) summary
      pfam13246
      Location:120 → 231
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 627
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    13. XM_036161206.1 → XP_036017099.1  probable phospholipid-transporting ATPase IIB isoform X7

      Conserved Domains (2) summary
      pfam13246
      Location:120 → 231
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 627
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    14. XM_036161204.1 → XP_036017097.1  probable phospholipid-transporting ATPase IIB isoform X6

      Conserved Domains (2) summary
      pfam13246
      Location:155 → 266
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1 → 662
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98195.4 GenPept UniProtKB/Swiss-Prot:P98195

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