Lpcat2b lysophosphatidylcholine acyltransferase 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpcat2bprovided by MGI
Official Full Name: lysophosphatidylcholine acyltransferase 2Bprovided by MGI
Primary source: MGI:MGI:1918152
See related: Ensembl:ENSMUSG00000033794 AllianceGenome:MGI:1918152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aytl1b; 4921521K07Rik
Summary: Predicted to enable acyltransferase activity and calcium ion binding activity. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; intestine; and respiratory system. Orthologous to human LPCAT2BP (lysophosphatidylcholine acyltransferase 2b, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 51.6) See more
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Genomic context

Location:: 5 F; 5 52.23 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (107579415..107582905)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (107431549..107435039)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophosphatidylcholine acyltransferase 2B

Names: acyltransferase like 1B; acyltransferase-like 1-B; lysophosphatidylcholine acyltransferase 2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027599.3 → NP_081875.1 lysophosphatidylcholine acyltransferase 2B

See identical proteins and their annotated locations for NP_081875.1

Status: VALIDATED

Source sequence(s)

AK029548, AV255931, BB572733, BY714455

Consensus CDS

CCDS19502.1

UniProtKB/Swiss-Prot

Q9D5U0

UniProtKB/TrEMBL

B2RT16

Related

ENSMUSP00000127318.2, ENSMUST00000166599.2

Conserved Domains (5) summary

cd07991
Location:111 → 323

LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

COG0204
Location:65 → 307

PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

cd00051
Location:392 → 454

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:392 → 453

EF-hand_7; EF-hand domain pair

cl08302
Location:429 → 487

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...