Noct nocturnin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Noctprovided by MGI
Official Full Name: nocturninprovided by MGI
Primary source: MGI:MGI:109382
See related: Ensembl:ENSMUSG00000023087 AllianceGenome:MGI:109382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccr4; Ccrn4l
Summary: Enables mRNA binding activity and poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation; and regulation of gene expression. Acts upstream of or within P-body assembly; circadian rhythm; and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; nucleus; and perinuclear region of cytoplasm. Is expressed in 2-cell stage embryo; central nervous system; and retina. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 54.9), colon adult (RPKM 24.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 22.12 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (51131868..51159075)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (51224447..51251654)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circadian control of Nocturnin and its regulatory role in health and disease.
Title: Circadian control of Nocturnin and its regulatory role in health and disease.
The Noct gene encodes a protein (NOC) that is highly conserved with the endonuclease/exonuclease/phosphatase (EEP) domain-containing CCR4 family of deadenylases, but highly purified NOC possesses little or no ribonuclease activity. NOC utilizes the dinucleotide NADP(H) as a substrate, removing the 2' phosphate to generate NAD(H), and is a direct regulator of oxidative stress response through its NADPH 2' phosphatase activ
Title: Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response.
posttranscriptional control by Nocturnin regulates the amplitude of critical metabolic pathways, and loss of this activity results in increased metabolic flux and reduced obesity
Title: Temporal Control of Metabolic Amplitude by Nocturnin.
Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs.
Title: Changes in poly(A) tail length dynamics from the loss of the circadian deadenylase Nocturnin.
precise expression of nocturnin is critical to proper development of early mouse embryos
Title: Functional analysis of nocturnin, a circadian deadenylase, at maternal-to-zygotic transition in mice.
Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes
Title: Nocturnin expression is induced by fasting in the white adipose tissue of restricted fed mice.
data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Title: The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice.
Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Title: An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis.
Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Title: Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes.
Noc interacts with Igf1 in a strain- and tissue-specific manner and reduces Igf1 expression by targeting the longer form of the Igf1 3'UTR.
Title: Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

px-30f4 (e-PCR)
- UniSTS:257566

D1Ertd309e (e-PCR), detects polymorphism
- UniSTS:167267

px-50g7 (e-PCR)
- UniSTS:257891

px-36f4 (e-PCR)
- UniSTS:257660

AU043840 (e-PCR)
- UniSTS:159112

px-58e10 (e-PCR)
- UniSTS:257966

PMC32249P1 (e-PCR)
- UniSTS:273126

RH126085 (e-PCR)
- UniSTS:162797

Ccrn4l (e-PCR), detects polymorphism
- UniSTS:536562

Ccrn4l (e-PCR), detects polymorphism
- UniSTS:536563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables NADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables NADPH phosphatase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A)-specific ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables poly(A)-specific ribonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within P-body assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nocturnin

Names: CCR4 carbon catabolite repression 4-like; CCR4 protein homolog; carbon catabolite repression 4 homolog; carbon catabolite repression 4-like protein; circadian deadenylase NOC

NP_033964.1

EC 3.1.3.108

XP_006501019.1

EC 3.1.3.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009834.2 → NP_033964.1 nocturnin

See identical proteins and their annotated locations for NP_033964.1

Status: VALIDATED

Source sequence(s)

AK084516, AK087790, BB261546

Consensus CDS

CCDS17336.1

UniProtKB/Swiss-Prot

O35710, Q9QZG9

UniProtKB/TrEMBL

B2RTJ8, Q3UEU2

Related

ENSMUSP00000023849.9, ENSMUST00000023849.15

Conserved Domains (1) summary

cd09096
Location:142 → 421

Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

51131868..51159075

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500956.1 → XP_006501019.1 nocturnin isoform X1

UniProtKB/TrEMBL

Q3UEU2

Conserved Domains (1) summary

cd09096
Location:85 → 364

Deadenylase_nocturnin; C-terminal deadenylase domain of nocturnin and related domains