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    ACKR3 atypical chemokine receptor 3 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 694428, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ACKR3provided by VGNC
    Official Full Name
    atypical chemokine receptor 3provided by VGNC
    Primary source
    VGNC:VGNC:69513
    Locus tag
    EGK_04929
    See related
    Ensembl:ENSMMUG00000060487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    CXCR7
    Orthologs
    human mouse all
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    Genomic context

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    See ACKR3 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (123965949..123980445)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (119253681..119268153)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene 60S ribosomal protein L3 pseudogene Neighboring gene uncharacterized LOC114671450 Neighboring gene uncharacterized LOC114671451 Neighboring gene uncharacterized LOC114671452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells. Jin J, et al. Ophthalmic Res, 2013. PMID 23549077
    2. TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression. Feng YF, et al. Mol Cell Biochem, 2014 Dec. PMID 25138701
    3. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Yan G, et al. Nat Biotechnol, 2011 Oct 16. PMID 22002653
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The increased CXCR4 and CXCR7 expression resulted in increased SDF-1-induced RF/6A cell migration and tube formation.
      Title: TGF-β1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression.
    2. The CXCR7/CXCR4/CXCL12 axis plays an important role in the formation of CNV, and may become a novel target for the treatment of choroidal neovascularization-associated diseases.
      Title: CXCR7/CXCR4/CXCL12 axis regulates the proliferation, migration, survival and tube formation of choroid-retinal endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chemokine binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    atypical chemokine receptor 3
    Names
    C-X-C chemokine receptor type 7
    chemokine (C-X-C motif) receptor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261729.1 → NP_001248658.1  atypical chemokine receptor 3

      See identical proteins and their annotated locations for NP_001248658.1

      Status: PROVISIONAL

      Source sequence(s)
      JV043892
      UniProtKB/TrEMBL
      A0A8J8YNH9, F7GTL4, G7N989
      Related
      ENSMMUP00000076930.1, ENSMMUT00000107472.1
      Conserved Domains (1) summary
      cd14987
      Location:45 → 326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      123965949..123980445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015111240.2 → XP_014966726.1  atypical chemokine receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8J8YNH9, F7GTL4, G7N989
      Conserved Domains (1) summary
      cd14987
      Location:45 → 326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_015111241.2 → XP_014966727.1  atypical chemokine receptor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8J8YNH9, F7GTL4, G7N989
      Conserved Domains (1) summary
      cd14987
      Location:45 → 326
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_028830379.1 → XP_028686212.1  atypical chemokine receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZVH9
      Related
      ENSMMUP00000068645.1, ENSMMUT00000083317.1
      Conserved Domains (1) summary
      cd14987
      Location:68 → 349
      7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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