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    Zfp653 zinc finger protein 653 [ Mus musculus (house mouse) ]

    Gene ID: 319601, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp653provided by MGI
    Official Full Name
    zinc finger protein 653provided by MGI
    Primary source
    MGI:MGI:2442362
    See related
    Ensembl:ENSMUSG00000038895 AllianceGenome:MGI:2442362
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zip67; Znf653; E430039K05Rik
    Summary
    Predicted to enable AF-2 domain binding activity and transcription corepressor activity. Predicted to be involved in extracellular negative regulation of signal transduction; negative regulation of nucleic acid-templated transcription; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF653 (zinc finger protein 653). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.9), ovary adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp653 in Genome Data Viewer
    Location:
    9 A3; 9 8.18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21966705..21982707, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (22055411..22071395, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein kinase C substrate 80K-H Neighboring gene ELAV like RNA binding protein 3 Neighboring gene predicted gene, 16845 Neighboring gene ECSIT signalling integrator Neighboring gene STARR-positive B cell enhancer ABC_E8280 Neighboring gene predicted gene 6581

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. Borud B, et al. Mol Endocrinol, 2003 Nov. PMID 12920234
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. novel zinc-finger protein that influences gene activation through interaction with the functionally important activation function-2 domain of nuclear receptors
      Title: Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AF-2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular negative regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular negative regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 653
    Names
    67 kDa zinc finger protein
    zinc finger protein Zip67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310759.2 → NP_001297688.1  zinc finger protein 653 isoform 1

      See identical proteins and their annotated locations for NP_001297688.1

      Status: VALIDATED

      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS80968.1
      UniProtKB/TrEMBL
      Q8BHR7
      Related
      ENSMUSP00000137064.2, ENSMUST00000179605.9
      Conserved Domains (3) summary
      COG5048
      Location:494 → 622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511 → 530
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:522 → 547
      zf-H2C2_2; Zinc-finger double domain

    2. NM_177318.4 → NP_796292.1  zinc finger protein 653 isoform 2

      See identical proteins and their annotated locations for NP_796292.1

      Status: VALIDATED

      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS22919.1
      UniProtKB/Swiss-Prot
      Q6YND2, Q8BHT8, Q8CI02
      Related
      ENSMUSP00000045895.7, ENSMUST00000043922.7
      Conserved Domains (3) summary
      COG5048
      Location:486 → 614
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:503 → 522
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:514 → 539
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21966705..21982707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510407.4 → XP_006510470.1  zinc finger protein 653 isoform X1

      Conserved Domains (1) summary
      pfam04979
      Location:391 → 444
      IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

    2. XM_036155049.1 → XP_036010942.1  zinc finger protein 653 isoform X2

    RNA

    1. XR_001778929.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6YND2.2 GenPept UniProtKB/Swiss-Prot:Q6YND2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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