Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnab3provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A regulatory beta subunit 3provided by RGD
Primary source: RGD:61830
See related: Ensembl:ENSRNOG00000008480 AllianceGenome:RGD:61830
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 48.3), Thymus (RPKM 17.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54546638..54555209)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54047830..54056401)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (55927228..55933653)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the auxiliary beta4-subunit has a function in rat large-conductance Ca(2+)-activated K(+) channel
Title: Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-3

Names: K(+) channel subunit beta-3; RCK beta3; kv-beta-3; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 3; potassium channel, voltage gated subfamily A regulatory beta subunit 3; potassium voltage gated channel, shaker related subfamily, beta member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031652.2 → NP_113840.1 voltage-gated potassium channel subunit beta-3

See identical proteins and their annotated locations for NP_113840.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q2KML7, Q63494

Related

ENSRNOP00000011523.3, ENSRNOT00000011523.6

Conserved Domains (2) summary

cd06660
Location:80 → 395

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

TIGR01293
Location:80 → 396

Kv_beta; voltage-dependent potassium channel beta subunit, animal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54546638..54555209

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086719.2 → XP_038942647.1 voltage-gated potassium channel subunit beta-3 isoform X1

Conserved Domains (1) summary

cl00470
Location:68 → 386

AKR_SF; Aldo-keto reductase (AKR) superfamily