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    Zfp462 zinc finger protein 462 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362522, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp462provided by RGD
    Official Full Name
    zinc finger protein 462provided by RGD
    Primary source
    RGD:1562123
    See related
    Ensembl:ENSRNOG00000032048 AllianceGenome:RGD:1562123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562123
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization and negative regulation of DNA binding activity. Predicted to be active in nucleus. Orthologous to human ZNF462 (zinc finger protein 462). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 94.2), Kidney (RPKM 50.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp462 in Genome Data Viewer
    Location:
    5q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (74465383..74606020)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (69670085..69810729)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (71679841..71824077)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478977 Neighboring gene cytochrome c oxidase subunit 6B1-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene 40S ribosomal protein S18-like Neighboring gene glutathione peroxidase 8, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA. Laurent A, et al. Mech Dev, 2007 May. PMID 17353115
    2. Involvement of ZFPIP/Zfp462 in chromatin integrity and survival of P19 pluripotent cells. Massé J, et al. Exp Cell Res, 2010 Apr 15. PMID 20219459
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 462

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427395.1 → NP_001414324.1  zinc finger protein 462

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZFG7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      74465383..74606020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111032.2 → XP_038966960.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2086 → 2106
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2084 → 2108
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. XM_063287930.1 → XP_063144000.1  zinc finger protein 462 isoform X2

    3. XM_039111033.2 → XP_038966961.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2086 → 2106
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2084 → 2108
      zf-H2C2_5; C2H2-type zinc-finger domain

    4. XM_039111031.2 → XP_038966959.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2086 → 2106
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2084 → 2108
      zf-H2C2_5; C2H2-type zinc-finger domain

    5. XM_039111037.2 → XP_038966965.1  zinc finger protein 462 isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:1162 → 1182
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:1160 → 1184
      zf-H2C2_5; C2H2-type zinc-finger domain

    6. XM_039111034.2 → XP_038966962.1  zinc finger protein 462 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:2086 → 2106
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:2084 → 2108
      zf-H2C2_5; C2H2-type zinc-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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