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    Dtd2 D-aminoacyl-tRNA deacylase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366619, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dtd2provided by RGD
    Official Full Name
    D-aminoacyl-tRNA deacylase 2provided by RGD
    Primary source
    RGD:1309138
    See related
    Ensembl:ENSRNOG00000006727 AllianceGenome:RGD:1309138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309138
    Summary
    Predicted to enable Ala-tRNA(Thr) hydrolase activity and D-tyrosyl-tRNA(Tyr) deacylase activity. Predicted to be involved in aminoacyl-tRNA metabolism involved in translational fidelity. Predicted to be active in cytoplasm. Orthologous to human DTD2 (D-aminoacyl-tRNA deacylase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 107.2), Kidney (RPKM 82.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtd2 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (75185496..75191774, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (69450146..69456430, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72781229..72786835, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479181 Neighboring gene HECT domain E3 ubiquitin protein ligase 1 Neighboring gene HEAT repeat containing 5A Neighboring gene uncharacterized LOC134479124 Neighboring gene G protein-coupled receptor 33, pseudogene 1 Neighboring gene tensin-2 pseudogene Neighboring gene NUBP iron-sulfur cluster assembly factor like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia. Kuncha SK, et al. Nat Commun, 2018 Feb 6. PMID 29410408, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Ala-tRNA(Thr) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    D-aminoacyl-tRNA deacylase 2
    Names
    D-tyrosyl-tRNA deacylase 2 (putative)
    probable D-tyrosyl-tRNA(Tyr) deacylase 2
    NP_001102451.1
    XP_038968558.1
    XP_038968559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108981.1 → NP_001102451.1  D-aminoacyl-tRNA deacylase 2

      See identical proteins and their annotated locations for NP_001102451.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBI1, B0K034, F7FIM5
      Related
      ENSRNOP00000009020.3, ENSRNOT00000009020.4
      Conserved Domains (1) summary
      pfam02580
      Location:12 → 167
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      75185496..75191774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112630.2 → XP_038968558.1  D-aminoacyl-tRNA deacylase 2 isoform X1

      Conserved Domains (1) summary
      pfam02580
      Location:1 → 108
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase

    2. XM_039112631.2 → XP_038968559.1  D-aminoacyl-tRNA deacylase 2 isoform X1

      Conserved Domains (1) summary
      pfam02580
      Location:1 → 108
      Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
    Nucleotide Protein Strain
    Heading Accession and Version

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