Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aimp1provided by RGD
Official Full Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by RGD
Primary source: RGD:620466
See related: Ensembl:ENSRNOG00000011384 AllianceGenome:RGD:620466
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Emap2; Scye1
Summary: Predicted to enable several functions, including GTPase binding activity; cytokine activity; and protein homodimerization activity. Involved in blood vessel morphogenesis and defense response to virus. Predicted to be located in cell surface; cytosol; and extracellular space. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Biomarker of myocardial infarction and neurodegenerative disease. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 200.0), Heart (RPKM 156.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (223825930..223849477, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (221151907..221175458, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (237727782..237751327, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EMAP2 decreases cell viability of rat C6 glioma cells. EMAP2 induces rat C6 glioma cells apoptosis via the mitochondrial pathway.
Title: Endothelial-monocyte-activating polypeptide II induces rat C6 glioma cell apoptosis via the mitochondrial pathway.
EMAP-II increases permeability through alpha-ATP synthase on the surface of brain microvascular endothelial cells.
Title: Mechanisms for endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier.
EMAP-II induces blood tumor barrier opening via the RhoA/Rho kinase/PKC-alpha/beta signaling pathways, however, PKC-zeta is involved in this process by other mechanisms.
Title: Signal mechanisms underlying low-dose endothelial monocyte-activating polypeptide-II-induced opening of the blood-tumor barrier.
The findings demonstrate that small inducible cytokine subfamily E member 1 interferes with alveolar cell transdifferentiation resulting in a proliferating non-myofibroblast cell.
Title: Endothelial-monocyte activating polypeptide II disrupts alveolar epithelial type II to type I cell transdifferentiation.
This study demonstrates for the first time that EMAP II increases the permeability of blood-tumor barrier selectively, and the possible mechanism is associated with the down-regulation of ZO-1, occludin and claudin-5.
Title: Endothelial-monocyte-activating polypeptide II increases blood-tumor barrier permeability by down-regulating the expression levels of tight junction associated proteins.
chemotactic molecule in the dental follicle involved in the recruitment of mononuclear cells directly and indirectly by enhancing the expression of other chemotactic molecules (colony-stimulating factor-1 and monocyte chemoattractant protein-1).
Title: Expression of endothelial monocyte-activating polypeptide II in the rat dental follicle and its potential role in tooth eruption.
EMAP-II expression is increased in LPS-induced acute lung inflammation, and that intra-tracheal instillation of mature EMAP-II induces recruitment of monocytes/macrophages and granulocytes into the lungs without stimulating IL-1beta or MIP-2 expression.
Title: Expression and function of endothelial monocyte-activating polypeptide-II in acute lung inflammation.
Temporospatial distribution of antiangiogenic protein EMAP II. Negative vascular modulators may have function in revascularization process following acute myocardial infarction.
Title: Potential role for antiangiogenic proteins in the myocardial infarction repair process.
Upregulation of EMAP-II by activated monocytes/microglial cells may serve as a sensitive marker of neurotoxic lesions in the brain.
Title: Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage.
An up to 30-fold increase in numbers of EMAP-2+ microglial cells and a massive expression by infiltrating macrophages at perivascular inflammatory foci is observed in Borna virus-infected brains, with a maximum on day 25 after infection.
Title: Accumulation of the proinflammatory cytokine endothelial-monocyte-activating polypeptide II in ramified microglial cells in brains of Borna virus infected Lewis rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d2rat138 (e-PCR)
- UniSTS:121631

RH128194 (e-PCR)
- UniSTS:211502

RH136362 (e-PCR)
- UniSTS:210352

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood vessel morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucagon secretion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Names: endothelial monocyte activating polypeptide 2; small inducible cytokine subfamily E, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053757.1 → NP_446209.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1

See identical proteins and their annotated locations for NP_446209.1

Status: PROVISIONAL

Source sequence(s)

BC098675

UniProtKB/TrEMBL

A0A8I5Y7U7, A0A8I6A263, A6HVT5, Q4G079

Related

ENSRNOP00000015213.4, ENSRNOT00000015213.7

Conserved Domains (2) summary

cd02799
Location:153 → 255

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

pfam07989
Location:31 → 79

Cnn_1N; Centrosomin N-terminal motif 1