Mettl23 methyltransferase 23, arginine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl23provided by RGD
Official Full Name: methyltransferase 23, arginineprovided by RGD
Primary source: RGD:1306284
See related: Ensembl:ENSRNOG00000000249 AllianceGenome:RGD:1306284
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306284
Summary: Predicted to enable DNA-binding transcription factor binding activity and heat shock protein binding activity. Predicted to be involved in cognition and positive regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human METTL23 (methyltransferase like 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 439.7), Spleen (RPKM 301.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102546102..102550782)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (102047090..102053379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (105787935..105793307)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11Wsu175e (e-PCR), detects polymorphism
- UniSTS:141827

RH133307 (e-PCR)
- UniSTS:216590

RH139654 (e-PCR)
- UniSTS:221738

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables histone H3R17 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3R17 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect epigenetic programing of male pronucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect epigenetic programing of male pronucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in epigenetic programming in the zygotic pronuclei	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programming in the zygotic pronuclei	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in female pronucleus	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in male pronucleus	ISO Inferred from Sequence Orthology more info
is_active_in male pronucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-arginine methyltransferase METTL23

Names: methyltransferase like 23; methyltransferase-like protein 23; probable methyltransferase-like protein 23

NP_001008284.1

EC 2.1.1.319

XP_006247860.1

EC 2.1.1.319

XP_038941626.1

EC 2.1.1.319

XP_063124861.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008283.1 → NP_001008284.1 histone-arginine methyltransferase METTL23

See identical proteins and their annotated locations for NP_001008284.1

Status: PROVISIONAL

Source sequence(s)

BC086594

UniProtKB/Swiss-Prot

Q5RJL2

UniProtKB/TrEMBL

A6HKZ5

Related

ENSRNOP00000000266.3, ENSRNOT00000000266.4

Conserved Domains (1) summary

cl17173
Location:35 → 161

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

102546102..102550782

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247798.4 → XP_006247860.1 histone-arginine methyltransferase METTL23 isoform X1

Conserved Domains (1) summary

cl17173
Location:8 → 134

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_039085698.2 → XP_038941626.1 histone-arginine methyltransferase METTL23 isoform X2

Conserved Domains (1) summary

cl17173
Location:35 → 141

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_063268791.1 → XP_063124861.1 histone-arginine methyltransferase METTL23 isoform X3