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    Uchl5 ubiquitin C-terminal hydrolase L5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360853, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Uchl5provided by RGD
    Official Full Name
    ubiquitin C-terminal hydrolase L5provided by RGD
    Primary source
    RGD:1305414
    See related
    Ensembl:ENSRNOG00000003545 AllianceGenome:RGD:1305414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in several processes, including brain development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of smoothened signaling pathway. Part of cytosolic proteasome complex. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 153.5), Thymus (RPKM 109.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uchl5 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (58070947..58106825)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (55520722..55556503)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (60568102..60603812)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 73 Neighboring gene uncharacterized LOC108352545 Neighboring gene glutaredoxin 2 Neighboring gene uncharacterized LOC120096268 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene Ro60, Y RNA binding protein Neighboring gene uncharacterized LOC103691931 Neighboring gene uncharacterized LOC102551374

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of testicular ischemia-reperfusion injury in rats. Ouh IO, et al. J Vet Med Sci, 2014 Mar. PMID 24189580, Free PMC Article
    2. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells. Ko YM, et al. Arch Biochem Biophys, 2013 Jul 15. PMID 23500140
    3. Chronic ethanol feeding affects proteasome-interacting proteins. Bousquet-Dubouch MP, et al. Proteomics, 2009 Jul. PMID 19609968, Free PMC Article
    4. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Matilainen O, et al. Cell Rep, 2013 Jun 27. PMID 23770237
    5. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Koulich E, et al. Mol Biol Cell, 2008 Mar. PMID 18162577, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in forebrain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lateral ventricle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase isozyme L5
    Names
    ubiquitin carboxyl-terminal esterase L5
    ubiquitin carboxyl-terminal hydrolase L5
    NP_001380778.1
    NP_001380779.1
    NP_001380780.1
    XP_038946829.1
    XP_063128542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393849.1 → NP_001380778.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K2A5, A0A8I6GL10, A6ICP4
      Related
      ENSRNOP00000094138.1, ENSRNOT00000098889.1
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264 → 309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    2. NM_001393850.1 → NP_001380779.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K2A5
      Related
      ENSRNOP00000072164.2, ENSRNOT00000077153.2
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:263 → 308
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    3. NM_001393851.1 → NP_001380780.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K2A5
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:235 → 271
      UCH_C; Ubiquitin carboxyl-terminal hydrolases

    4. NM_001429622.1 → NP_001416551.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    5. NM_001429623.1 → NP_001416552.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RNA

    1. NR_172020.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    2. NR_190751.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      58070947..58106825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272472.1 → XP_063128542.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

    2. XM_039090901.2 → XP_038946829.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2A5, Q5HZY3
      Related
      ENSRNOP00000004881.4
      Conserved Domains (2) summary
      cd02255
      Location:8 → 223
      Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
      pfam18031
      Location:264 → 309
      UCH_C; Ubiquitin carboxyl-terminal hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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