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    Kif7 kinesin family member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293047, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kif7provided by RGD
    Official Full Name
    kinesin family member 7provided by RGD
    Primary source
    RGD:1310310
    See related
    Ensembl:ENSRNOG00000026857 AllianceGenome:RGD:1310310
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in microtubule-based movement; negative regulation of smoothened signaling pathway; and positive regulation of smoothened signaling pathway. Predicted to act upstream of or within aorta development; cardiac septum development; and coronary vasculature development. Predicted to be located in ciliary basal body. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Biomarker of congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in acrocallosal syndrome; cleft lip; and hydrolethalus syndrome 2. Orthologous to human KIF7 (kinesin family member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 42.6), Lung (RPKM 31.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif7 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143041206..143067873, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133639487..133658539, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141434183..141452592, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cullin 4B, pseudogene 1 Neighboring gene uncharacterized LOC120099869 Neighboring gene TOPBP1-interacting checkpoint and replication regulator Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene uncharacterized LOC120099868 Neighboring gene perilipin 1 Neighboring gene peroxisomal biogenesis factor 11 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population. de Araujo TK, et al. J Craniomaxillofac Surg, 2016 Jan. PMID 26602496
    2. Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia. Takahashi T, et al. J Pediatr Surg, 2015 Jun. PMID 25921351
    3. Novel KIF7 mutations extend the phenotypic spectrum of acrocallosal syndrome. Putoux A, et al. J Med Genet, 2012 Nov. PMID 23125460
    4. KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Putoux A, et al. Nat Genet, 2011 Jun. PMID 21552264, Free PMC Article
    5. Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics. Dafinger C, et al. J Clin Invest, 2011 Jul. PMID 21633164, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased Kif7 expression during diaphragmatic development may result in diaphragmatic defects in the nitrofen-induced congenital diaphragmatic hernia model.
      Title: Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143041206..143067873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229415.5 → XP_006229477.1  kinesin-like protein KIF7 isoform X3

      See identical proteins and their annotated locations for XP_006229477.1

      Conserved Domains (4) summary
      smart00129
      Location:15 → 356
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:700 → 1039
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:15 → 350
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cl02164
      Location:847 → 1027
      Utp11; Utp11 protein

    2. XM_063278924.1 → XP_063134994.1  kinesin-like protein KIF7 isoform X4

    3. XM_006229414.5 → XP_006229476.1  kinesin-like protein KIF7 isoform X2

      See identical proteins and their annotated locations for XP_006229476.1

      Conserved Domains (4) summary
      smart00129
      Location:15 → 356
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:700 → 1039
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:15 → 350
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cl02164
      Location:847 → 1027
      Utp11; Utp11 protein

    4. XM_218828.11 → XP_218828.5  kinesin-like protein KIF7 isoform X1

      See identical proteins and their annotated locations for XP_218828.5

      UniProtKB/TrEMBL
      D4A9P0
      Related
      ENSRNOP00000038247.4
      Conserved Domains (4) summary
      smart00129
      Location:15 → 356
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1340
      Location:701 → 1040
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01372
      Location:15 → 350
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      cl02164
      Location:848 → 1028
      Utp11; Utp11 protein

    RNA

    1. XR_010060620.1 RNA Sequence

    2. XR_005499265.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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