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    Trmt44 tRNA methyltransferase 44 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305443, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Trmt44provided by RGD
    Official Full Name
    tRNA methyltransferase 44provided by RGD
    Primary source
    RGD:1308380
    See related
    Ensembl:ENSRNOG00000008898 AllianceGenome:RGD:1308380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mettl19; RGD1308380
    Summary
    Predicted to enable tRNA (uracil) methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytoplasm. Orthologous to human TRMT44 (tRNA methyltransferase 44 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 47.6), Liver (RPKM 46.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt44 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79399943..79424761)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75175331..75204291)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80361490..80379408)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene HtrA serine peptidase 3 Neighboring gene acyl-CoA oxidase 3, pristanoyl Neighboring gene carboxypeptidase Z Neighboring gene uncharacterized LOC120096640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (uridine) methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable tRNA (uracil-O(2)-)-methyltransferase
    Names
    methyltransferase like 19
    tRNA methyltransferase 44 homolog
    NP_001123533.1
    XP_038947891.2
    XP_038947892.2
    XP_038947893.1
    XP_038947894.1
    XP_038947895.1
    XP_038947896.2
    XP_038947898.1
    XP_038947899.2
    XP_063129221.1
    XP_063129222.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130061.1 → NP_001123533.1  probable tRNA (uracil-O(2)-)-methyltransferase

      See identical proteins and their annotated locations for NP_001123533.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A6IJZ6, D3ZS79
      Related
      ENSRNOP00000011824.4, ENSRNOT00000011824.7
      Conserved Domains (1) summary
      pfam07757
      Location:242 → 353
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79399943..79424761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091965.2 → XP_038947893.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X3

      Conserved Domains (1) summary
      pfam07757
      Location:67 → 178
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    2. XM_039091967.2 → XP_038947895.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X4

      Conserved Domains (1) summary
      pfam07757
      Location:55 → 166
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    3. XM_039091963.2 → XP_038947891.2  probable tRNA (uracil-O(2)-)-methyltransferase isoform X1

      UniProtKB/TrEMBL
      D3ZS79

    4. XM_039091964.2 → XP_038947892.2  probable tRNA (uracil-O(2)-)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      D3ZS79

    5. XM_063273151.1 → XP_063129221.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      D3ZS79

    6. XM_063273152.1 → XP_063129222.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X2

      UniProtKB/TrEMBL
      D3ZS79

    7. XM_039091971.2 → XP_038947899.2  probable tRNA (uracil-O(2)-)-methyltransferase isoform X7

    8. XM_039091968.2 → XP_038947896.2  probable tRNA (uracil-O(2)-)-methyltransferase isoform X5

    9. XM_039091966.2 → XP_038947894.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X4

      Conserved Domains (1) summary
      pfam07757
      Location:55 → 166
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase

    10. XM_039091970.2 → XP_038947898.1  probable tRNA (uracil-O(2)-)-methyltransferase isoform X6

      Conserved Domains (1) summary
      pfam07757
      Location:38 → 125
      AdoMet_MTase; Predicted AdoMet-dependent methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version

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