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    Bet1l Bet1 golgi vesicular membrane trafficking protein like [ Mus musculus (house mouse) ]

    Gene ID: 54399, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bet1lprovided by MGI
    Official Full Name
    Bet1 golgi vesicular membrane trafficking protein likeprovided by MGI
    Primary source
    MGI:MGI:1913128
    See related
    Ensembl:ENSMUSG00000025484 AllianceGenome:MGI:1913128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gs15; 2610021K23Rik
    Summary
    Enables SNAP receptor activity. Predicted to be involved in regulation of retrograde vesicle-mediated transport, Golgi to ER and retrograde transport, endosome to Golgi. Located in Golgi membrane and Golgi stack. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human BET1L (Bet1 golgi vesicular membrane trafficking protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.1), limb E14.5 (RPKM 16.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bet1l in Genome Data Viewer
    Location:
    7 F4; 7 86.05 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140433297..140437306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140853384..140857156, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C330022C24 gene Neighboring gene secretoglobin, family 1C, member 1 Neighboring gene ciliary microtubule associated protein 1A Neighboring gene STARR-positive B cell enhancer ABC_E1748 Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene sirtuin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9304 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain. Nagy G, et al. Mol Biol Cell, 2005 Dec. PMID 16195346, Free PMC Article
    2. GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. Xu Y, et al. J Biol Chem, 1997 Aug 8. PMID 9242691
    3. Myb proteins regulate the expression of diverse target genes. Lang G, et al. Oncogene, 2005 Feb 17. PMID 15608679
    4. The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network. Zeng Q, et al. J Biol Chem, 2003 Jun 20. PMID 12682051
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two amino acidubstitutions do not regulate secretion by affecting the property of SNARE complex itself.
      Title: Alternative splicing of SNAP-25 regulates secretion through nonconservative substitutions in the SNARE domain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of retrograde vesicle-mediated transport, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi-associated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BET1-like protein
    Names
    GOS-15
    blocked early in transport 1 homolog-like
    golgi SNARE with a size of 15 kDa
    golgi SNARE, 15 kD
    soluble N-ethylmaleimide-sensitive factor attachment protein (SNARE) 15
    vesicle transport protein GOS15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018742.5 → NP_061212.3  BET1-like protein

      See identical proteins and their annotated locations for NP_061212.3

      Status: VALIDATED

      Source sequence(s)
      AK011508, AK161239, BY292666
      Consensus CDS
      CCDS21987.1
      UniProtKB/Swiss-Prot
      O35153, Q9D0E4
      UniProtKB/TrEMBL
      A0A1B0GS34
      Related
      ENSMUSP00000026557.9, ENSMUST00000026557.10
      Conserved Domains (1) summary
      cd15853
      Location:18 → 76
      SNARE_Bet1; SNARE motif of Bet1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140433297..140437306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242798.2 → XP_030098658.1  BET1-like protein isoform X1

      UniProtKB/Swiss-Prot
      O35153, Q9D0E4
      UniProtKB/TrEMBL
      A0A1B0GS34
      Conserved Domains (1) summary
      cd15853
      Location:18 → 76
      SNARE_Bet1; SNARE motif of Bet1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35153.1 GenPept UniProtKB/Swiss-Prot:O35153

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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