U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kctd10 potassium channel tetramerisation domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 330171, updated on 9-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kctd10provided by MGI
    Official Full Name
    potassium channel tetramerisation domain containing 10provided by MGI
    Primary source
    MGI:MGI:2141207
    See related
    Ensembl:ENSMUSG00000001098 AllianceGenome:MGI:2141207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mBACURD3
    Summary
    Predicted to enable Notch binding activity and identical protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within angiogenesis; heart development; and negative regulation of Notch signaling pathway. Part of MKS complex. Is expressed in clavicle; mandible; maxilla; midgut; and rib. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 118.3), colon adult (RPKM 56.8) and 27 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Kctd10 in Genome Data Viewer
    Location:
    5 F; 5 55.99 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114501633..114518566, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114363572..114380505, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetyl-Coenzyme A carboxylase beta Neighboring gene STARR-seq mESC enhancer starr_14069 Neighboring gene STARR-seq mESC enhancer starr_14070 Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene myosin 1H Neighboring gene ubiquitin protein ligase E3B Neighboring gene microRNA 7027 Neighboring gene STARR-positive B cell enhancer ABC_E278 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling. Ye MS, et al. J Endocrinol, 2022 Jan 13. PMID 34854382
    2. Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape? Navarro N, et al. G3 (Bethesda), 2016 May 3. PMID 26921296, Free PMC Article
    3. KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development. Ren K, et al. PLoS One, 2014. PMID 25401743, Free PMC Article
    4. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Chih B, et al. Nat Cell Biol, 2011 Dec 18. PMID 22179047
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
      Title: KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13.
    2. KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
      Title: KCTD10 regulates brown adipose tissue thermogenesis and metabolic function via Notch signaling.
    3. Our studies suggest that KCTD10 plays crucial roles in embryonic angiogenesis and heart development in mammalians by negatively regulating the Notch signaling pathway.
      Title: KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC11654

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MKS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MKS complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
    Names
    BTB/POZ domain-containing protein KCTD10
    potassium channel tetramerization domain-containing 10

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159941.1 → NP_001153413.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147714, AK161199, BB855690, BQ571808
      Consensus CDS
      CCDS51623.1
      UniProtKB/TrEMBL
      F8WGQ9
      Related
      ENSMUSP00000001125.6, ENSMUST00000001125.6
      Conserved Domains (2) summary
      smart00225
      Location:33 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:34 → 124
      BTB_2; BTB/POZ domain

    2. NM_026145.4 → NP_080421.2  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

      See identical proteins and their annotated locations for NP_080421.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, which results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK147714, AK161199, BB855690
      Consensus CDS
      CCDS19563.1
      UniProtKB/Swiss-Prot
      Q922M3
      Related
      ENSMUSP00000099641.5, ENSMUST00000102581.11
      Conserved Domains (2) summary
      smart00225
      Location:33 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:34 → 124
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114501633..114518566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922M3.1 GenPept UniProtKB/Swiss-Prot:Q922M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous