Ctsr cathepsin R [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctsrprovided by MGI
Official Full Name: cathepsin Rprovided by MGI
Primary source: MGI:MGI:1861723
See related: Ensembl:ENSMUSG00000055679 AllianceGenome:MGI:1861723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including collagen binding activity; fibronectin binding activity; and serpin family protein binding activity. Predicted to be involved in several processes, including collagen catabolic process; proteolysis; and viral entry into host cell. Predicted to act upstream of or within protein catabolic process. Predicted to be located in Golgi apparatus; multivesicular body; and plasma membrane. Predicted to be active in extracellular space and lysosome. Is expressed in brain; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward placenta adult (RPKM 141.9) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13 B2; 13 32.67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (61307029..61312002, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (61159215..61164188, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Possible association of cathepsins with placental lactogen-II may play important roles in placental functions during the latter half of pregnancy in mice.
Title: Cathepsin gene expression in mouse placenta during the latter half of pregnancy.
chromosome mapping of this enzyme in mouse placenta.
Title: Assignment of murine placental cathepsin R to mouse chromosome bands 13B2-B3 by fluorescence in situ hybridization.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

mHAa31g11.seq (e-PCR)
- UniSTS:125977

AI428350 (e-PCR)
- UniSTS:180548

Ctsr (e-PCR), detects polymorphism
- UniSTS:256972

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein catabolic process	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cathepsin R

Names: lysosomal cysteine protease

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020284.1 → NP_064680.1 cathepsin R precursor

See identical proteins and their annotated locations for NP_064680.1

Status: PROVISIONAL

Source sequence(s)

AF245399

Consensus CDS

CCDS26585.1

UniProtKB/Swiss-Prot

Q9JIA9

UniProtKB/TrEMBL

Q497X4, Q58IU7

Related

ENSMUSP00000021889.5, ENSMUST00000021889.6

Conserved Domains (3) summary

PTZ00203
Location:15 → 332

PTZ00203; cathepsin L protease; Provisional

smart00848
Location:29 → 87

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:116 → 332

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...