Siglecf sialic acid binding Ig-like lectin F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Siglecfprovided by MGI
Official Full Name: sialic acid binding Ig-like lectin Fprovided by MGI
Primary source: MGI:MGI:2681107
See related: Ensembl:ENSMUSG00000039013 AllianceGenome:MGI:2681107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Siglec5; mSiglec-F
Summary: Enables monosaccharide binding activity and sialic acid binding activity. Involved in regulation of endocytosis. Located in lysosome. Orthologous to several human genes including SIGLEC6 (sialic acid binding Ig like lectin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 6.0), small intestine adult (RPKM 1.8) and 11 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43000496..43008899)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43351341..43359475)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of Siglec-F[hi]CD101[hi] eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
Title: Induction of Siglec-F(hi)CD101(hi) eosinophils in the lungs following murine hookworm Nippostrongylus brasiliensis infection.
Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
Title: Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis.
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils.
Title: IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F(+) neutrophils.
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Title: Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.
Title: A novel Siglec-F(+) neutrophil subset in the mouse nasal mucosa exhibits an activated phenotype and is increased in an allergic rhinitis model.
the knockdown of Siglec-F enhanced GM-CSF-induced STAT5 phosphorylation and reduced the STAT6 phosphorylation and expression of arginase-1 in interleukin-4-stimulated macrophages
Title: Siglec-F is induced by granulocyte-macrophage colony-stimulating factor and enhances interleukin-4-induced expression of arginase-1 in mouse macrophages.
Immunohistochemical analysis of the Peyer's patches (PPs) tissue sections shows that Siglec-F is expressed on the surface of the Intestinal microfold (M) cell membrane exposed to the intestinal lumen.
Title: Siglec-F is a novel intestinal M cell marker.
These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.
Title: Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.
depending on the nature of the allergy model used, the negative regulatory role of siglec-F on eosinophilia may be overridden.
Title: Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model.
Engagement of Siglec-F induced mouse eosinophil apoptosis that was modest in magnitude and dependent on caspase activity.
Title: Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sialic acid-binding Ig-like lectin 5

Names: sialic acid-binding lectin Siglec-F; siglec-5; siglec-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271019.1 → NP_001257948.1 sialic acid-binding Ig-like lectin 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_001257948.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AF293371, BB842394, BC145038

Consensus CDS

CCDS85278.1

UniProtKB/TrEMBL

B7ZN64, Q80ZE2

Related

ENSMUSP00000146009.2, ENSMUST00000206299.2

Conserved Domains (2) summary

smart00410
Location:252 → 325

IG_like; Immunoglobulin like

cl11960
Location:20 → 132

Ig; Immunoglobulin domain
NM_145581.2 → NP_663556.1 sialic acid-binding Ig-like lectin 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_663556.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes a longer isoform (1).

Source sequence(s)

AF293371, BB842394

Consensus CDS

CCDS21167.1

UniProtKB/Swiss-Prot

Q920G3

UniProtKB/TrEMBL

Q80ZE2

Related

ENSMUSP00000012798.8, ENSMUST00000012798.14

Conserved Domains (2) summary

smart00410
Location:252 → 325

IG_like; Immunoglobulin like

cl11960
Location:20 → 132

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43000496..43008899

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152965.1 → XP_036008858.1 sialic acid-binding Ig-like lectin 5 isoform X1

UniProtKB/TrEMBL

Q80ZE2

Conserved Domains (3) summary

smart00409
Location:272 → 345

IG; Immunoglobulin

cd00096
Location:40 → 44

Ig; Ig strand A [structural motif]

cl11960
Location:40 → 153

Ig; Immunoglobulin domain
XM_036152966.1 → XP_036008859.1 sialic acid-binding Ig-like lectin 5 isoform X2

UniProtKB/TrEMBL

Q80ZE2

Conserved Domains (3) summary

smart00409
Location:272 → 345

IG; Immunoglobulin

cd00096
Location:40 → 44

Ig; Ig strand A [structural motif]

cl11960
Location:40 → 153

Ig; Immunoglobulin domain
XM_006540816.1 → XP_006540879.1 sialic acid-binding Ig-like lectin 5 isoform X3

See identical proteins and their annotated locations for XP_006540879.1

UniProtKB/TrEMBL

Q80ZE2

Conserved Domains (2) summary

smart00410
Location:252 → 325

IG_like; Immunoglobulin like

cl11960
Location:20 → 132

Ig; Immunoglobulin domain