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    Pde4c phosphodiesterase 4C, cAMP specific [ Mus musculus (house mouse) ]

    Gene ID: 110385, updated on 9-May-2024

    Summary

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    Official Symbol
    Pde4cprovided by MGI
    Official Full Name
    phosphodiesterase 4C, cAMP specificprovided by MGI
    Primary source
    MGI:MGI:99556
    See related
    Ensembl:ENSMUSG00000031842 AllianceGenome:MGI:99556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dpde1; dunce; E130301F19Rik
    Summary
    Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and signal transduction. Located in cilium. Is expressed in brain; gonad; metanephros; and submandibular gland. Orthologous to human PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 28.4), liver adult (RPKM 8.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde4c in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71176485..71203835)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70723835..70751186)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing N Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene STARR-positive B cell enhancer ABC_E1370 Neighboring gene STARR-positive B cell enhancer ABC_E190 Neighboring gene RAB3A, member RAS oncogene family Neighboring gene MPV17 mitochondrial membrane protein-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning, tissue distribution, gene structure, functional characterization, and transcriptional regulation thyroid hormone. Lee A, et al. DNA Cell Biol, 2003 Jan. PMID 12590734
    2. Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice. Boyd A, et al. Biology (Basel), 2021 Dec 20. PMID 34943270, Free PMC Article
    3. Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice. Aragon IV, et al. Biochem Pharmacol, 2021 Apr. PMID 33609559, Free PMC Article
    4. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. McDonough W, et al. FASEB J, 2020 Sep. PMID 32738081, Free PMC Article
    5. Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion. Tian G, et al. J Cell Sci, 2012 Nov 1. PMID 22946044

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31320

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4C
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C
    cAMP-specific phosphodiesterase 4C
    NP_001297394.1
    NP_963901.1
    XP_011240550.1
    XP_011240560.1
    XP_011240561.1
    XP_011240562.1
    XP_030099101.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310465.1 → NP_001297394.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform 1

      See identical proteins and their annotated locations for NP_001297394.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC162446, AK149514
      Consensus CDS
      CCDS80891.1
      UniProtKB/Swiss-Prot
      Q3UEI1, Q8K0P4
      UniProtKB/TrEMBL
      A0A6I8MX13
      Related
      ENSMUSP00000105722.3, ENSMUST00000110095.3
      Conserved Domains (1) summary
      pfam00233
      Location:388 → 629
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_201607.2 → NP_963901.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform 2

      See identical proteins and their annotated locations for NP_963901.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC162446, AK053713, AK149514
      Consensus CDS
      CCDS22378.1
      UniProtKB/TrEMBL
      A0A6I8MX13
      Related
      ENSMUSP00000034307.8, ENSMUST00000034307.14
      Conserved Domains (1) summary
      pfam00233
      Location:388 → 595
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71176485..71203835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242258.4 → XP_011240560.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X2

      Conserved Domains (2) summary
      pfam00233
      Location:447 → 564
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:213 → 329
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    2. XM_011242248.4 → XP_011240550.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X1

      See identical proteins and their annotated locations for XP_011240550.1

      UniProtKB/TrEMBL
      A0A6I8MX13
      Related
      ENSMUSP00000159363.2, ENSMUST00000239435.2
      Conserved Domains (2) summary
      pfam00233
      Location:447 → 688
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:213 → 329
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    3. XM_011242259.3 → XP_011240561.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

      See identical proteins and their annotated locations for XP_011240561.1

      Conserved Domains (1) summary
      pfam00233
      Location:221 → 462
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_011242260.4 → XP_011240562.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X3

      See identical proteins and their annotated locations for XP_011240562.1

      Conserved Domains (1) summary
      pfam00233
      Location:221 → 462
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_030243241.1 → XP_030099101.1  3',5'-cyclic-AMP phosphodiesterase 4C isoform X4

      Conserved Domains (1) summary
      pfam00233
      Location:100 → 341
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UEI1.1 GenPept UniProtKB/Swiss-Prot:Q3UEI1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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