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    Gsto2 glutathione S-transferase omega 2 [ Mus musculus (house mouse) ]

    Gene ID: 68214, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gsto2provided by MGI
    Official Full Name
    glutathione S-transferase omega 2provided by MGI
    Primary source
    MGI:MGI:1915464
    See related
    Ensembl:ENSMUSG00000025069 AllianceGenome:MGI:1915464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GSTO 2-2; 1700020F09Rik; 4930425C18Rik
    Summary
    Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 98.1) See more
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    Genomic context

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    See Gsto2 in Genome Data Viewer
    Location:
    19 D1; 19 40.41 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47853879..47874747)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47865438..47886308)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46374 Neighboring gene STARR-positive B cell enhancer ABC_E1529 Neighboring gene predicted gene, 30021 Neighboring gene glutathione S-transferase omega 1 Neighboring gene STARR-positive B cell enhancer ABC_E1530 Neighboring gene STARR-positive B cell enhancer ABC_E7670 Neighboring gene VISTA enhancer mm324 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47994118-47994301 Neighboring gene STARR-positive B cell enhancer mm9_chr19:48011969-48012270 Neighboring gene cilia and flagella associated protein 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in mice†. Hamilton LE, et al. Biol Reprod, 2019 Aug 1. PMID 31087045
    2. The developmental origin and compartmentalization of glutathione-s-transferase omega 2 isoforms in the perinuclear theca of eutherian spermatozoa. Hamilton LE, et al. Biol Reprod, 2017 Oct 1. PMID 29036365, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.
      Title: Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.
    2. Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in micedagger.
      Title: Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in mice†.
    3. GSTO2 is transported and deposited in the postacrosomal sheath (PAS) region by the manchette, and that the late assembly of GSTO2 and its localization in the PAS suggests a role in regulating the oxidative and reductive state of covalently linked spermatid/sperm proteins, especially during the disassembly of the sperm accessory structures after fertilization
      Title: The developmental origin and compartmentalization of glutathione-s-transferase omega 2 isoforms in the perinuclear theca of eutherian spermatozoa.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione dehydrogenase (ascorbate) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione dehydrogenase (ascorbate) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylarsonate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-ascorbic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-ascorbic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase omega-2
    Names
    GSTO-2
    MMA(V) reductase
    glutathione S-transferase omega 2-2
    glutathione-dependent dehydroascorbate reductase
    monomethylarsonic acid reductase
    NP_080895.2
    NP_084327.1
    XP_030106922.1
    XP_030106923.1
    XP_030106924.1
    XP_036017568.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026619.2 → NP_080895.2  glutathione S-transferase omega-2

      See identical proteins and their annotated locations for NP_080895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK018953, AK075753, AK077086
      Consensus CDS
      CCDS29894.1
      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Related
      ENSMUSP00000052592.5, ENSMUST00000056159.11
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_030051.1 → NP_084327.1  glutathione S-transferase omega-2

      See identical proteins and their annotated locations for NP_084327.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK077086
      Consensus CDS
      CCDS29894.1
      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Related
      ENSMUSP00000113409.2, ENSMUST00000120645.8
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      47853879..47874747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251062.2 → XP_030106922.1  glutathione S-transferase omega-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. XM_030251064.2 → XP_030106924.1  glutathione S-transferase omega-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    3. XM_030251063.1 → XP_030106923.1  glutathione S-transferase omega-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    4. XM_036161675.1 → XP_036017568.1  glutathione S-transferase omega-2 isoform X1

      UniProtKB/Swiss-Prot
      Q8K2Q2
      UniProtKB/TrEMBL
      Q8BW12, Q9D2S1
      Conserved Domains (2) summary
      cd03184
      Location:108 → 230
      GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
      cd03055
      Location:6 → 94
      GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2Q2.1 GenPept UniProtKB/Swiss-Prot:Q8K2Q2

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