Cd99 CD99 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd99provided by MGI
Official Full Name: CD99 antigenprovided by MGI
Primary source: MGI:MGI:1913728
See related: AllianceGenome:MGI:1913728
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D4; Pilr-l; pilr-1; 1110061M03Rik; 2410026K10Rik
Summary: Acts upstream of or within several processes, including T cell extravasation; myeloid dendritic cell activation; and positive regulation of neutrophil extravasation. Located in cell surface. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and lung. Orthologous to human CD99 (CD99 molecule (Xg blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4 Unlocalized Scaffold	NT_187055.1 (48..1475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4 Unlocalized Scaffold	NT_187055.1 (48..1475, complement)

NT_187055.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upon neutrophil arrest, binding of PILR-beta1 to CD99 ceases, shifting the signaling balance towards inhibitory PILR-alpha. This enables integrin deactivation and supports cell diapedesis in venules of the mouse cremaster muscle.
Title: Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.
endothelial CD99 promotes leukocyte attachment to endothelium in inflamed vessels by a heterophilic ligand. In addition, CD99 binds to PILRs on neutrophils, an interaction that leads to increased shear resistance of the neutrophil attachment to ICAM-1.
Title: Endothelial CD99 supports arrest of mouse neutrophils in venules and binds to neutrophil PILRs.
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Title: Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
role in membrane trafficking of CD99L2 and in controlling transendothelial migration of leukocytes
Title: Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.
CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells.
Title: CD99-dependent expansion of myeloid-derived suppressor cells and attenuation of graft-versus-host disease.
Mouse CD99 is expressed on mouse leukocytes as well as enriched at the endothelial cell borders.
Title: CD99 is essential for leukocyte diapedesis in vivo.
Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice.
Title: Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient mice.
These findings indicate that sialylated O-linked sugar structures on CD99 play an important role in the recognition of PILR.
Title: An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR).
CD99L2 and CD99 are involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum
Title: A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell extravasation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell extravasation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid dendritic cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil extravasation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neutrophil extravasation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CD99 antigen

Names: paired immunoglobin-like type 2 receptor-ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.