Klf13 Kruppel-like transcription factor 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf13provided by MGI
Official Full Name: Kruppel-like transcription factor 13provided by MGI
Primary source: MGI:MGI:1354948
See related: Ensembl:ENSMUSG00000052040 AllianceGenome:MGI:1354948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bteb3; FKLF2; NSLP1; FKLF-2; RFLAT1; RFLAT-1; 0610043C13Rik; 9430029L20Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation and negative regulation of erythrocyte differentiation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and neural retina. Orthologous to human KLF13 (Kruppel like factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 63.8), lung adult (RPKM 36.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 C; 7 34.58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (63536099..63588663, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (63886351..63938915, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
Title: KLF13 overexpression protects sepsis-induced myocardial injury and LPS-induced inflammation and apoptosis.
KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
Title: KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF.
The Paralogous Kruppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
Title: The Paralogous Krüppel-like Factors 9 and 13 Regulate the Mammalian Cellular Circadian Clock Output Gene Dbp.
the improvement of cardiac function and structure elicited by miR-125b-5p is in part attributed to repression of the pro-apoptotic genes Bak1 and Klf13 in cardiomyocytes.
Title: A carvedilol-responsive microRNA, miR-125b-5p protects the heart from acute myocardial infarction by repressing pro-apoptotic bak1 and klf13 in cardiomyocytes.
Methylation levels at cg07814318 also positively correlated with ghrelin levels. Moreover, expression of KLF13 was augmented in the brains of obese and starved mice
Title: A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.
These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
Title: Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
The data also suggest that, in human, KLF13 may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.
Title: KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.
Results demonstrate lack of a causative relationship between endometrial KLF13 deficiency and lesion establishment in mice, and they support the broader participation of multiple signaling pathways in the pathology of endometriosis.
Title: Krüppel-Like Factor 13 Deficiency in Uterine Endometrial Cells Contributes to Defective Steroid Hormone Receptor Signaling but Not Lesion Establishment in a Mouse Model of Endometriosis.
KLF13 directly binds to IL-4 promoter regions and synergizes with c-Maf to positively regulate IL-4 expression.
Title: KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.
Fbw7 gamma - mediated ubiquitination of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.
Title: Fbw7γ-mediated degradation of KLF13 prevents RANTES expression in resting human but not murine T lymphocytes.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Klf13 (e-PCR), detects polymorphism
- UniSTS:547253

Klf13 (e-PCR), detects polymorphism
- UniSTS:275688

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 13

Names: BTE-binding protein 3; C2-H2 zinc finger protein; Kruppel-like factor 13; RANTES factor of late activated T-lymphocytes 1; basic transcription element-binding protein 3; erythroid transcription factor FKLF-2; transcription factor BTEB3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021366.3 → NP_067341.2 Krueppel-like factor 13

See identical proteins and their annotated locations for NP_067341.2

Status: VALIDATED

Source sequence(s)

AC127344, AC148977

Consensus CDS

CCDS21331.1

UniProtKB/Swiss-Prot

Q9ESX3, Q9JHF8, Q9JJZ6

UniProtKB/TrEMBL

Q3U2G6

Related

ENSMUSP00000067680.8, ENSMUST00000063694.10

Conserved Domains (2) summary

COG5048
Location:163 → 253

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:170 → 192

ZF_C2H2; C2H2 Zn finger [structural motif]