Tg thyroglobulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgprovided by MGI
Official Full Name: thyroglobulinprovided by MGI
Primary source: MGI:MGI:98733
See related: Ensembl:ENSMUSG00000053469 AllianceGenome:MGI:98733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tgn; cog
Summary: Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; autoimmune thyroiditis; goiter; and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.0), genital fat pad adult (RPKM 0.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D2; 15 29.3 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (66542606..66722570)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (66670754..66850721)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
Title: Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin.
Title: Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin.
antepenultimate residue of TG as a major T3-forming site, but also demonstrate that the side chain of this residue intimately interacts with the same residue in the apposed monomer of the TG dimer.
Title: Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.
Findings suggest that coumestrol treatment may have some beneficial actions against thyroid-specific thyroglobulin (Tg) autoantibody production in the development of autoimmune thyroiditis through suppression of Th1 response.
Title: Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.
these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT.
Title: The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.
Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin.
Title: Maturation of thyroglobulin protein region I.
The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy.
Title: Evaluation of thyroglobulin expression in murine reproductive organs during pregnancy.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
Title: Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
These results indicate that Runx2 deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism.
Title: Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism.
Development of iodine-accelerated autoimmune thyroiditis in NOD.H2h4 mice is not associated with enhanced iodine organification or differential B- or T-cell responses to iodinated determinants in Tg.
Title: Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (7) 1 citation
Endonuclease-mediated (5) 1 citation
Spontaneous (1)
Transgenic (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sla (e-PCR), detects polymorphism
- UniSTS:144406

D11S3038 (e-PCR)
- UniSTS:152140

Tg (e-PCR), detects polymorphism
- UniSTS:516180

Sla (e-PCR), detects polymorphism
- UniSTS:507225

D15Mit211 (e-PCR), detects polymorphism
- UniSTS:127580

D15Mit106 (e-PCR), detects polymorphism
- UniSTS:127465

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anion binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within iodide transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pH	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone generation	IDA Inferred from Direct Assay more info	PubMed
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thyroglobulin

Names: congenital goiter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009375.2 → NP_033401.2 thyroglobulin precursor

See identical proteins and their annotated locations for NP_033401.2

Status: VALIDATED

Source sequence(s)

BC111467, CK788949, CK789624, U76389

Consensus CDS

CCDS37091.1

UniProtKB/Swiss-Prot

O08710, O88590, Q2NKY1, Q9QWY7

Related

ENSMUSP00000070239.8, ENSMUST00000065916.14

Conserved Domains (5) summary

smart00211
Location:1519 → 1566

TY; Thyroglobulin type I repeats

cd00191
Location:96 → 161

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam00135
Location:2192 → 2717

COesterase; Carboxylesterase family

pfam07699
Location:1464 → 1509

GCC2_GCC3; GCC2 and GCC3

cl00150
Location:893 → 922

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

66542606..66722570

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520745.4 → XP_006520808.2 thyroglobulin isoform X1

Conserved Domains (5) summary

smart00211
Location:1519 → 1566

TY; Thyroglobulin type I repeats

cd00191
Location:96 → 161

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

pfam07699
Location:1464 → 1509

Ephrin_rec_like; Putative ephrin-receptor like

pfam00135
Location:2198 → 2717

COesterase; Carboxylesterase family

cl00150
Location:893 → 922

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases