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    Xkr9 X-linked Kx blood group related 9 [ Mus musculus (house mouse) ]

    Gene ID: 381246, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Xkr9provided by MGI
    Official Full Name
    X-linked Kx blood group related 9provided by MGI
    Primary source
    MGI:MGI:2686466
    See related
    Ensembl:ENSMUSG00000067813 AllianceGenome:MGI:2686466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XRG9; Gm1620
    Summary
    Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Located in plasma membrane. Is expressed in midgut. Orthologous to human XKR9 (XK related 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 3.4), large intestine adult (RPKM 2.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xkr9 in Genome Data Viewer
    Location:
    1 A3; 1 4.31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (13738962..13772454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (13668738..13702230)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene translocating chain-associating membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_00279 Neighboring gene lactamase, beta 2 Neighboring gene STARR-seq mESC enhancer starr_00283 Neighboring gene STARR-seq mESC enhancer starr_00284 Neighboring gene predicted gene, 26273 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exposure of phosphatidylserine by Xk-related protein family members during apoptosis. Suzuki J, et al. J Biol Chem, 2014 Oct 31. PMID 25231987, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unlike Xkr8, which is ubiquitously expressed, Xkr4 and Xkr9 expression is tissue-specific.
      Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process involved in development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in engulfment of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylserine exposure on apoptotic cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    XK-related protein 9
    Names
    X Kell blood group precursor related family member 9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011873.2 → NP_001011873.1  XK-related protein 9

      See identical proteins and their annotated locations for NP_001011873.1

      Status: PROVISIONAL

      Source sequence(s)
      AC116708
      Consensus CDS
      CCDS14824.1
      UniProtKB/Swiss-Prot
      B2RWB3, Q5GH62
      UniProtKB/TrEMBL
      B2RY73
      Related
      ENSMUSP00000085900.4, ENSMUST00000088542.4
      Conserved Domains (1) summary
      pfam09815
      Location:13 → 346
      XK-related; XK-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      13738962..13772454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495548.3 → XP_006495611.1  XK-related protein 9 isoform X2

      Conserved Domains (1) summary
      pfam09815
      Location:1 → 233
      XK-related; XK-related protein

    2. XM_006495547.4 → XP_006495610.1  XK-related protein 9 isoform X1

      See identical proteins and their annotated locations for XP_006495610.1

      UniProtKB/Swiss-Prot
      B2RWB3, Q5GH62
      UniProtKB/TrEMBL
      B2RY73
      Conserved Domains (1) summary
      pfam09815
      Location:13 → 346
      XK-related; XK-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GH62.1 GenPept UniProtKB/Swiss-Prot:Q5GH62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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