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    Macc1 metastasis associated in colon cancer 1 [ Mus musculus (house mouse) ]

    Gene ID: 238455, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Macc1provided by MGI
    Official Full Name
    metastasis associated in colon cancer 1provided by MGI
    Primary source
    MGI:MGI:2685113
    See related
    Ensembl:ENSMUSG00000041886 AllianceGenome:MGI:2685113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm267; 4732474O15Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in epithelium of phallic urethra of male and urethral plate. Orthologous to human MACC1 (MET transcriptional regulator MACC1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in bladder adult (RPKM 1.7), limb E14.5 (RPKM 0.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Macc1 in Genome Data Viewer
    Location:
    12 F2; 12 63.48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119354133..119430669)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119390398..119466934)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46331 Neighboring gene PRA1 domain family 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33457 Neighboring gene NOP2 nucleolar protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_33458 Neighboring gene STARR-seq mESC enhancer starr_33459 Neighboring gene STARR-seq mESC enhancer starr_33460 Neighboring gene STARR-seq mESC enhancer starr_33461 Neighboring gene 60S ribosomal protein L5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer. Sun L, et al. Cancer Lett, 2015 Feb 1. PMID 25444928
    2. In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice. Pichorner A, et al. Clin Exp Metastasis, 2012 Aug. PMID 22484916
    3. Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice. Chen XP, et al. Mol Biol Rep, 2014 Mar. PMID 24469707
    4. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Stein U, et al. Nat Med, 2009 Jan. PMID 19098908
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
      Title: Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer.
    2. HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
      Title: Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.
    3. MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
      Title: In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
    4. MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
      Title: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    metastasis-associated in colon cancer protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163136.1 → NP_001156608.1  metastasis-associated in colon cancer protein 1

      See identical proteins and their annotated locations for NP_001156608.1

      Status: VALIDATED

      Source sequence(s)
      AC132596, AC138307
      Consensus CDS
      CCDS49199.1
      UniProtKB/TrEMBL
      E9PXX8
      Related
      ENSMUSP00000042955.7, ENSMUST00000048880.7
      Conserved Domains (2) summary
      pfam07653
      Location:552 → 616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219 → 290
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      119354133..119430669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515863.3 → XP_006515926.1  metastasis-associated in colon cancer protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515926.1

      UniProtKB/TrEMBL
      E9PXX8
      Conserved Domains (2) summary
      pfam07653
      Location:552 → 616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219 → 290
      ZU5; ZU5 domain

    2. XM_006515861.4 → XP_006515924.1  metastasis-associated in colon cancer protein 1 isoform X1

      Conserved Domains (2) summary
      pfam07653
      Location:562 → 626
      SH3_2; Variant SH3 domain
      cl02517
      Location:229 → 300
      ZU5; ZU5 domain

    3. XM_006515862.2 → XP_006515925.1  metastasis-associated in colon cancer protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006515925.1

      UniProtKB/TrEMBL
      E9PXX8
      Related
      ENSMUSP00000152123.2, ENSMUST00000222058.2
      Conserved Domains (2) summary
      pfam07653
      Location:552 → 616
      SH3_2; Variant SH3 domain
      cl02517
      Location:219 → 290
      ZU5; ZU5 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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