Smdt1 single-pass membrane protein with aspartate rich tail 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smdt1provided by MGI
Official Full Name: single-pass membrane protein with aspartate rich tail 1provided by MGI
Primary source: MGI:MGI:1916279
See related: Ensembl:ENSMUSG00000022452 AllianceGenome:MGI:1916279
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Emre; 1500032L24Rik
Summary: Predicted to be involved in calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to act upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in nervous system; neural retina; orbito-sphenoid; and vibrissa. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 154.0), duodenum adult (RPKM 148.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.56 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82229901..82233266)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82346046..82349062)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.
Title: Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.
MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
Title: Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: essential MCU regulator, mitochondrial

Names: UPF0466 protein C22orf32 homolog, mitochondrial; single-pass membrane protein with aspartate-rich tail 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026914.1 → NP_081190.1 essential MCU regulator, mitochondrial precursor

See identical proteins and their annotated locations for NP_081190.1

Status: PROVISIONAL

Source sequence(s)

BC028457

Consensus CDS

CCDS27688.1

UniProtKB/Swiss-Prot

Q58EA5, Q9DB10

Related

ENSMUSP00000023086.9, ENSMUST00000023086.15

Conserved Domains (1) summary

pfam10161
Location:33 → 101

DDDD; Putative mitochondrial precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

82229901..82233266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159567.1 → XP_036015460.1 essential MCU regulator, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q58EA5, Q9DB10

Conserved Domains (1) summary

pfam10161
Location:33 → 101

DDDD; Putative mitochondrial precursor protein