Galm galactose mutarotase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Galmprovided by MGI
Official Full Name: galactose mutarotaseprovided by MGI
Primary source: MGI:MGI:2442420
See related: Ensembl:ENSMUSG00000035473 AllianceGenome:MGI:2442420
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A530057M15Rik
Summary: Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 44.1), liver adult (RPKM 34.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 50.46 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (80434886..80492461)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (80127458..80185032)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237709

AU020959 (e-PCR)
- UniSTS:160700

AU015645 (e-PCR)
- UniSTS:209343

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldose 1-epimerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose 1-epimerase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
NOT enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in galactose catabolic process via UDP-galactose	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose catabolic process via UDP-galactose	ISO Inferred from Sequence Orthology more info	PubMed
involved_in galactose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hexose metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: galactose mutarotase

Names: aldose 1-epimerase

NP_795937.1

EC 5.1.3.3

XP_006524453.1

EC 5.1.3.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176963.4 → NP_795937.1 galactose mutarotase

See identical proteins and their annotated locations for NP_795937.1

Status: PROVISIONAL

Source sequence(s)

AC140361

Consensus CDS

CCDS28987.1

UniProtKB/Swiss-Prot

Q8K157

UniProtKB/TrEMBL

Q3TSZ4

Related

ENSMUSP00000040580.5, ENSMUST00000039205.11

Conserved Domains (1) summary

cd09019
Location:21 → 339

galactose_mutarotase_like; galactose mutarotase_like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

80434886..80492461

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524390.5 → XP_006524453.1 galactose mutarotase isoform X1

Conserved Domains (1) summary

cd09019
Location:21 → 211

galactose_mutarotase_like; galactose mutarotase_like