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    Zbtb22 zinc finger and BTB domain containing 22 [ Mus musculus (house mouse) ]

    Gene ID: 81630, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Zbtb22provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 22provided by MGI
    Primary source
    MGI:MGI:1931870
    See related
    Ensembl:ENSMUSG00000051390 AllianceGenome:MGI:1931870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bing1; Zfp297; 1110008J20Rik
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and nucleus pulposus. Orthologous to human ZBTB22 (zinc finger and BTB domain containing 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 44.7), ovary adult (RPKM 43.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb22 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34135150..34138299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33916176..33919325)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5591 Neighboring gene cDNA sequence BC051226 Neighboring gene Fas death domain-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E4207 Neighboring gene STARR-positive B cell enhancer ABC_E5592 Neighboring gene STARR-positive B cell enhancer ABC_E7521 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene ral guanine nucleotide dissociation stimulator-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis. Liu N, et al. EMBO Rep, 2023 Jun 5. PMID 37154299, Free PMC Article
    2. The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene. Logunova N, et al. PLoS Genet, 2015 Nov. PMID 26618355, Free PMC Article
    3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
    4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis.
      Title: Hepatic ZBTB22 promotes hyperglycemia and insulin resistance via PEPCK1-driven gluconeogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 22
    Names
    zinc finger protein 297

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020625.3 → NP_065650.1  zinc finger and BTB domain-containing protein 22

      See identical proteins and their annotated locations for NP_065650.1

      Status: VALIDATED

      Source sequence(s)
      BC052154, BY011334
      Consensus CDS
      CCDS28634.1
      UniProtKB/Swiss-Prot
      Q9Z0G7
      UniProtKB/TrEMBL
      Q3TW94, Q3TXW4
      Related
      ENSMUSP00000057466.10, ENSMUST00000053429.11
      Conserved Domains (5) summary
      smart00225
      Location:58 → 147
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:485 → 504
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:47 → 147
      BTB; BTB/POZ domain
      pfam13465
      Location:524 → 547
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34135150..34138299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0G7.1 GenPept UniProtKB/Swiss-Prot:Q9Z0G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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