Pea15b-ps proliferation and apoptosis adaptor protein 15B, pseudogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pea15b-psprovided by MGI
Official Full Name: proliferation and apoptosis adaptor protein 15B, pseudogeneprovided by MGI
Primary source: MGI:MGI:3525016
See related: AllianceGenome:MGI:3525016
Gene type: pseudo
RefSeq status: INFERRED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pea15b
Summary: Is expressed in telencephalon and ventricular layer. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 5 C3.3; 5 41.9 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77657786..77659595, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (77509939..77511748, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vanishin translocates to the nucleus and retains ERK in the nucleus in the absence of stimulation of the ERK/MAPK pathway. It also inhibits ERK activation and ERK-dependent transcription without altering MEK activity.
Title: Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

astrocytic phosphoprotein PEA-15 pseudogene
phosphoprotein enriched in astrocytes 15A pseudogene
phosphoprotein enriched in astrocytes 15B, pseudogene
vanishin

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mitogen-activated protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_041816.2

Range

101..1910

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GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

77657786..77659595 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001010832.1: Suppressed sequence

Description

NM_001010832.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NR_027806.1: Suppressed sequence

Description

NR_027806.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.