Tfap4 transcription factor AP4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tfap4provided by MGI
Official Full Name: transcription factor AP4provided by MGI
Primary source: MGI:MGI:103239
See related: Ensembl:ENSMUSG00000005718 AllianceGenome:MGI:103239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AP-4; Tcfap4; bHLHc41; D930048N17Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in cellular response to dexamethasone stimulus; negative regulation of macromolecule metabolic process; and protein-containing complex assembly. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and gut. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.45 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4362525..4378625, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4544661..4560762, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.
Title: Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis.
TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
Title: TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
Title: AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p.
Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes.
Title: Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes.
Results establish Ap4 as rate-limiting mediator of adenoma initiation, as well as regulator of intestinal and colonic stem cell and Paneth cell homeostasis.
Title: Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.
AP4 integrates T-cell-mediated selection and sustained expansion of GC B cells for humoral immunity.
Title: The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses.
results indicate that AP4 is a central mediator and coordinator of cell cycle progression
Title: AP4 is required for mitogen- and c-MYC-induced cell cycle progression.
Induction of AP4 by c-myc maintains CD8+ T cell activation.
Title: c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.
Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss.
Title: AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.
AP4 contributes to Cd4 silencing both in DN and CD8(+) T cells by enforcing checkpoints for appropriate timing of CD4 expression and its epigenetic silencing.
Title: Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237415

AI642933 (e-PCR)
- UniSTS:180852

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to dexamethasone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: transcription factor AP-4

Names: transcription factor AP-4 (activating enhancer-binding protein 4)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419427.1 → NP_001406356.1 transcription factor AP-4 isoform 2

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419428.1 → NP_001406357.1 transcription factor AP-4 isoform 3

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419429.1 → NP_001406358.1 transcription factor AP-4 isoform 4

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419430.1 → NP_001406359.1 transcription factor AP-4 isoform 5

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419431.1 → NP_001406360.1 transcription factor AP-4 isoform 6

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419432.1 → NP_001406361.1 transcription factor AP-4 isoform 6

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419433.1 → NP_001406362.1 transcription factor AP-4 isoform 6

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419434.1 → NP_001406363.1 transcription factor AP-4 isoform 6

Status: VALIDATED

Source sequence(s)

AC157597
NM_001419435.1 → NP_001406364.1 transcription factor AP-4 isoform 7

Status: VALIDATED

Source sequence(s)

AC157597
NM_031182.3 → NP_112459.1 transcription factor AP-4 isoform 1

See identical proteins and their annotated locations for NP_112459.1

Status: VALIDATED

Source sequence(s)

AC157597

Consensus CDS

CCDS27919.1

UniProtKB/TrEMBL

Q8BWA4, Q9JIZ5

Related

ENSMUSP00000005862.8, ENSMUST00000005862.9

Conserved Domains (1) summary

pfam00010
Location:49 → 100

HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

4362525..4378625 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522766.5 → XP_006522829.1 transcription factor AP-4 isoform X2

See identical proteins and their annotated locations for XP_006522829.1

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006522765.4 → XP_006522828.1 transcription factor AP-4 isoform X2

See identical proteins and their annotated locations for XP_006522828.1

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_011246047.3 → XP_011244349.1 transcription factor AP-4 isoform X2

See identical proteins and their annotated locations for XP_011244349.1

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_030249340.1 → XP_030105200.1 transcription factor AP-4 isoform X2

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_006522763.5 → XP_006522826.1 transcription factor AP-4 isoform X2

See identical proteins and their annotated locations for XP_006522826.1

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_017317166.3 → XP_017172655.1 transcription factor AP-4 isoform X1

UniProtKB/TrEMBL

Q8BWA4

Conserved Domains (1) summary

cd11419
Location:26 → 86

bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins