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    Mturn maturin, neural progenitor differentiation regulator homolog (Xenopus) [ Mus musculus (house mouse) ]

    Gene ID: 68235, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mturnprovided by MGI
    Official Full Name
    maturin, neural progenitor differentiation regulator homolog (Xenopus)provided by MGI
    Primary source
    MGI:MGI:1915485
    See related
    Ensembl:ENSMUSG00000038065 AllianceGenome:MGI:1915485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410066E13Rik; B230212L03Rik
    Summary
    Involved in positive regulation of megakaryocyte differentiation. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; ileum; male reproductive gland or organ; notochord; and retina. Orthologous to human MTURN (maturin, neural progenitor differentiation regulator homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 30.4), CNS E14 (RPKM 17.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mturn in Genome Data Viewer
    Location:
    6 B3; 6 27.07 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54658609..54680840)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54681624..54703855)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 14 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 Neighboring gene STARR-seq mESC enhancer starr_15954 Neighboring gene predicted gene, 34249 Neighboring gene STARR-seq mESC enhancer starr_15956 Neighboring gene STARR-seq mESC enhancer starr_15957 Neighboring gene predicted gene, 44008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:54760023-54760206 Neighboring gene STARR-positive B cell enhancer ABC_E10381 Neighboring gene zinc and ring finger 2 Neighboring gene STARR-seq mESC enhancer starr_15969 Neighboring gene nucleotide-binding oligomerization domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C-Jun/C7ORF41/NF-κB axis mediates hepatic inflammation and lipid accumulation in NAFLD. Yan FJ, et al. Biochem J, 2020 Feb 14. PMID 31957809
    2. C7ORF41 Regulates Inflammation by Inhibiting NF-κB Signaling Pathway. Zhou J, et al. Biomed Res Int, 2021. PMID 33506033, Free PMC Article
    3. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. Sun X, et al. Blood Cancer J, 2014 Mar 28. PMID 24681962, Free PMC Article
    4. Maturin is a novel protein required for differentiation during primary neurogenesis. Martinez-De Luna RI, et al. Dev Biol, 2013 Dec 1. PMID 24095902, Free PMC Article
    5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    maturin
    Names
    UPF0452 protein C7orf41 homolog
    maturin neural progenitor differentiation regulator protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289740.1 → NP_001276669.1  maturin isoform a

      See identical proteins and their annotated locations for NP_001276669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC084800, BC052467, BY266709
      Consensus CDS
      CCDS20158.2
      UniProtKB/Swiss-Prot
      Q8CGA4
      Related
      ENSMUSP00000140586.2, ENSMUST00000190641.7
      Conserved Domains (1) summary
      pfam15167
      Location:4 → 131
      DUF4581; Domain of unknown function (DUF4581)

    2. NM_001289741.1 → NP_001276670.1  maturin isoform b

      See identical proteins and their annotated locations for NP_001276670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 3' exon structure, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
      Source sequence(s)
      AC084800, BC052467, BY266709
      Consensus CDS
      CCDS80537.1
      UniProtKB/TrEMBL
      A0A087WQV4
      Related
      ENSMUSP00000140358.2, ENSMUST00000187701.2
      Conserved Domains (1) summary
      pfam15167
      Location:4 → 129
      DUF4581; Domain of unknown function (DUF4581)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54658609..54680840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241447.3 → XP_011239749.1  maturin isoform X1

      See identical proteins and their annotated locations for XP_011239749.1

      UniProtKB/TrEMBL
      A0A087WQV4
      Conserved Domains (1) summary
      pfam15167
      Location:4 → 129
      DUF4581; Domain of unknown function (DUF4581)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026629.3: Suppressed sequence

      Description
      NM_026629.3: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGA4.1 GenPept UniProtKB/Swiss-Prot:Q8CGA4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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