Or4e2 olfactory receptor family 4 subfamily E member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or4e2provided by MGI
Official Full Name: olfactory receptor family 4 subfamily E member 2provided by MGI
Primary source: MGI:MGI:3031343
See related: Ensembl:ENSMUSG00000035626 AllianceGenome:MGI:3031343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Or83; Mor83; MOR244-3; Olfr1509
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.95 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52687850..52688859)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (52450393..52451402)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Experimental and computational study supports an atomistic structural model of the MOR244-3 binding site that consists of copper ion bound to H105, C109, and N202 in an internal aqueous channel of the transmembrane G-protein-coupled receptor
Title: QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491432

Olfr1509 (e-PCR), detects polymorphism
- UniSTS:526062

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables copper ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables odorant binding	IBA Inferred from Biological aspect of Ancestor more info
enables odorant binding	IDA Inferred from Direct Assay more info	PubMed
enables odorant binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: olfactory receptor 4E2

Names: GA_x6K02T2RJGY-534312-533386; gene for odorant receptor MOR83; odorant receptor 244-3; odorant receptor 83; odorant receptor MOR83; olfactory receptor 1509; olfactory receptor MOR244-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007044.1

Range

22927..23936

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_020514.2 → NP_065260.2 olfactory receptor 4E2

See identical proteins and their annotated locations for NP_065260.2

Status: VALIDATED

Source sequence(s)

BC119199

Consensus CDS

CCDS27060.1

UniProtKB/Swiss-Prot

A0A0U1RP41, Q7TQQ0, Q9R0K3

Related

ENSMUSP00000046688.3, ENSMUST00000045066.3

Conserved Domains (1) summary

cd15940
Location:25 → 291

7tmA_OR4E-like; olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors