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    Zfp661 zinc finger protein 661 [ Mus musculus (house mouse) ]

    Gene ID: 72180, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfp661provided by MGI
    Official Full Name
    zinc finger protein 661provided by MGI
    Primary source
    MGI:MGI:1919430
    See related
    Ensembl:ENSMUSG00000034800 AllianceGenome:MGI:1919430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A1-5; Znf2; 2810405K07Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF2 (zinc finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.6), CNS E14 (RPKM 1.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp661 in Genome Data Viewer
    Location:
    2 F1; 2 62.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127416537..127429014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127574617..127587094, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35478 Neighboring gene prominin 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127385126-127385426 Neighboring gene predicted gene 14229 Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene STARR-seq mESC enhancer starr_05627 Neighboring gene STARR-seq mESC enhancer starr_05628 Neighboring gene myelin and lymphocyte protein, T cell differentiation protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Kim SS, et al. Proc Natl Acad Sci U S A, 1996 Dec 24. PMID 8986806, Free PMC Article
    2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 2
    Names
    zfp-661
    zinc finger protein 2 (A1-5)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111029.1 → NP_001104499.1  zinc finger protein 2 isoform a

      See identical proteins and their annotated locations for NP_001104499.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK033122, AL731831
      Consensus CDS
      CCDS16705.1
      UniProtKB/Swiss-Prot
      Q7TPW3, Q8BIQ3
      Related
      ENSMUSP00000076637.6, ENSMUST00000077422.12
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:153 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001355622.1 → NP_001342551.1  zinc finger protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK134651, AL731831
      Consensus CDS
      CCDS16705.1
      UniProtKB/Swiss-Prot
      Q7TPW3, Q8BIQ3
      Related
      ENSMUSP00000105995.2, ENSMUST00000110366.8
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:153 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001355623.1 → NP_001342552.1  zinc finger protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL731831
      Conserved Domains (3) summary
      smart00349
      Location:2 → 52
      KRAB; krueppel associated box
      COG5048
      Location:131 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:205 → 225
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_028141.3 → NP_082417.3  zinc finger protein 2 isoform a

      See identical proteins and their annotated locations for NP_082417.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AL731831, BC052876
      Consensus CDS
      CCDS16705.1
      UniProtKB/Swiss-Prot
      Q7TPW3, Q8BIQ3
      Related
      ENSMUSP00000105997.3, ENSMUST00000110368.9
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:153 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      127416537..127429014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252108.2 → XP_030107968.1  zinc finger protein 2 isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:44 → 94
      KRAB; krueppel associated box
      COG5048
      Location:173 → 437
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036162588.1 → XP_036018481.1  zinc finger protein 2 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:113 → 377
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:12 → 34
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_011239788.4 → XP_011238090.1  zinc finger protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011238090.1

      UniProtKB/Swiss-Prot
      Q7TPW3, Q8BIQ3
      Conserved Domains (3) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:153 → 417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_011239787.4 → XP_011238089.1  zinc finger protein 2 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:51 → 101
      KRAB; krueppel associated box
      COG5048
      Location:180 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036162589.1 → XP_036018482.1  zinc finger protein 2 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:113 → 377
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:12 → 34
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. XM_030252107.2 → XP_030107967.1  zinc finger protein 2 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:51 → 101
      KRAB; krueppel associated box
      COG5048
      Location:180 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030252111.1 → XP_030107971.1  zinc finger protein 2 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:113 → 377
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:12 → 34
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    8. XM_036162590.1 → XP_036018483.1  zinc finger protein 2 isoform X5

      Conserved Domains (3) summary
      COG5048
      Location:97 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:73 → 93
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:29 → 54
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIQ3.1 GenPept UniProtKB/Swiss-Prot:Q8BIQ3

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