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    Lyg1 lysozyme G-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 69541, updated on 8-May-2024

    Summary

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    Official Symbol
    Lyg1provided by MGI
    Official Full Name
    lysozyme G-like 1provided by MGI
    Primary source
    MGI:MGI:1916791
    See related
    Ensembl:ENSMUSG00000026085 AllianceGenome:MGI:1916791
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2300002O18Rik
    Summary
    Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. Orthologous to human LYG1 (lysozyme g1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 4.2) and lung adult (RPKM 1.3) See more
    Orthologs
    human all
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    Genomic context

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    See Lyg1 in Genome Data Viewer
    Location:
    1 B; 1 16.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37985819..37996840, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37946738..37957759, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene lysozyme G-like 2 Neighboring gene STARR-seq mESC enhancer starr_00687 Neighboring gene thioredoxin domain containing 9 Neighboring gene STARR-positive B cell enhancer ABC_E3269 Neighboring gene STARR-positive B cell enhancer ABC_E10006 Neighboring gene eukaryotic translation initiation factor 5B Neighboring gene STARR-seq mESC enhancer starr_00688 Neighboring gene predicted gene, 34448

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells. Liu H, et al. Front Immunol, 2021. PMID 34262560, Free PMC Article
    2. LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4(+) T cells. Liu H, et al. Oncoimmunology, 2017. PMID 28507796, Free PMC Article
    3. Molecular evolution of vertebrate goose-type lysozyme genes. Irwin DM, et al. J Mol Evol, 2003 Feb. PMID 12574869
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells.
      Title: LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease via Skewing Allogeneic T Cells Polarization Towards Treg Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme g-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027111.3 → NP_081387.1  lysozyme g-like protein 1 precursor

      See identical proteins and their annotated locations for NP_081387.1

      Status: PROVISIONAL

      Source sequence(s)
      AK009014
      Consensus CDS
      CCDS35543.1
      UniProtKB/Swiss-Prot
      Q9D7Q0
      UniProtKB/TrEMBL
      F8WIW2, Q0VE18
      Related
      ENSMUSP00000110544.2, ENSMUST00000114894.2
      Conserved Domains (1) summary
      cl00222
      Location:38 → 195
      lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      37985819..37996840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496258.1 → XP_006496321.1  lysozyme g-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F8WIW2
      Conserved Domains (1) summary
      cl00222
      Location:38 → 158
      Lyz-like; lysozyme-like domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7Q0.1 GenPept UniProtKB/Swiss-Prot:Q9D7Q0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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