Cyld CYLD lysine 63 deubiquitinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyldprovided by MGI
Official Full Name: CYLD lysine 63 deubiquitinaseprovided by MGI
Primary source: MGI:MGI:1921506
See related: Ensembl:ENSMUSG00000036712 AllianceGenome:MGI:1921506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EAC; CDMT; CYLD1; mKIAA0849; 2010013M14Rik; 2900009M21Rik; C130039D01Rik
Summary: This gene encodes a protein that is a member of the ubiquitin C-terminal hydrolase subfamily of the deubiquitinating enzyme family. Members of this family catalyze the removal of ubiquitin from a substrate or another ubiquitin molecule and thereby play important roles in regulating signaling pathways, recycling ubiquitin and regulating protein stability. This protein removes ubiquitin from K-63-linked ubiquitin chains from proteins involved in NF-kappaB signaling and thus acts as a negative regulator of this pathway. In humans mutations in this gene have been associated with cylindromatosis, an autosomal dominant predisposition to tumors of skin appendages. In mouse deficiency of this gene impairs thymocyte development and increases susceptibility to skin and colon tumors. A pseudogene of this gene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 5.8), cortex adult (RPKM 5.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 43.51 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (89423506..89478574)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (88696878..88751946)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development.
Title: Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development.
CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.
Title: CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1.
miR-130b regulates B cell proliferation via CYLD-mediated NF-kappaB signaling.
Title: miR-130b regulates B cell proliferation via CYLD-mediated NF-κB signaling.
Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice.
Title: Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice.
CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis.
Title: CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis.
CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart.
Title: CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart.
Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.
Title: Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.
Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.
Title: Impact of CYLD on chromatin structure and histone methylation in malignant melanoma.
Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.
Title: Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death.
CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth.
Title: CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables Met1-linked polyubiquitin deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K63-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein linear deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein linear deubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of necroptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ripoptosome assembly involved in necroptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
colocalizes_with cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with midbody	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase CYLD

Names: cylindromatosis (turban tumor syndrome); deubiquitinating enzyme CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD

NP_001121642.1

EC 3.4.19.12

NP_001121643.1

EC 3.4.19.12

NP_001263208.1

EC 3.4.19.12

NP_775545.1

EC 3.4.19.12

XP_006531477.1

EC 3.4.19.12

XP_006531478.1

EC 3.4.19.12

XP_006531479.1

EC 3.4.19.12

XP_006531480.1

EC 3.4.19.12

XP_006531481.1

EC 3.4.19.12

XP_006531482.1

EC 3.4.19.12

XP_006531483.1

EC 3.4.19.12

XP_011246825.1

EC 3.4.19.12

XP_011246826.1

EC 3.4.19.12

XP_011246827.1

EC 3.4.19.12

XP_030099667.1

EC 3.4.19.12

XP_030099668.1

EC 3.4.19.12

XP_030099669.1

EC 3.4.19.12

XP_030099671.1

EC 3.4.19.12

XP_030099672.1

EC 3.4.19.12

XP_036010220.1

EC 3.4.19.12

XP_036010221.1

EC 3.4.19.12

XP_036010222.1

EC 3.4.19.12

XP_036010223.1

EC 3.4.19.12

XP_036010225.1

EC 3.4.19.12

XP_036010226.1

EC 3.4.19.12

XP_036010227.1

EC 3.4.19.12

XP_036010228.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128170.2 → NP_001121642.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform a

See identical proteins and their annotated locations for NP_001121642.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame exon in the coding region compared to variant 2. It encodes isoform a which is longer than isoform b.

Source sequence(s)

AC138025, AC156937, AK147204

Consensus CDS

CCDS52633.1

UniProtKB/TrEMBL

Z4YJJ5

Related

ENSMUSP00000147654.2, ENSMUST00000209532.2

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001128171.2 → NP_001121643.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform b

See identical proteins and their annotated locations for NP_001121643.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Both variants 2 and 4 encode isoform b.

Source sequence(s)

AC138025, AC156937

Consensus CDS

CCDS22513.1

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Related

ENSMUSP00000148037.2, ENSMUST00000211554.2

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_001276279.1 → NP_001263208.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform c

See identical proteins and their annotated locations for NP_001263208.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as short (s)-CYLD) differs in the 5' UTR and lacks several alternate exons in the coding region compared to variant 2. It encodes isoform c which is shorter than isoform b.

Source sequence(s)

AC138025, AC156937

Consensus CDS

CCDS85579.1

UniProtKB/TrEMBL

A0A1B0GSE5, Q3TJI3

Related

ENSMUSP00000147904.2, ENSMUST00000209206.2

Conserved Domains (3) summary

smart01052
Location:127 → 203

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:407 → 762

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 375

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
NM_173369.3 → NP_775545.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform b

See identical proteins and their annotated locations for NP_775545.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes isoform b. Both variants 2 and 4 encode isoform b.

Source sequence(s)

AC138025, AC156937

Consensus CDS

CCDS22513.1

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Related

ENSMUSP00000147426.2, ENSMUST00000209559.2

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

89423506..89478574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243811.1 → XP_030099671.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531419.2 → XP_006531482.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X3

UniProtKB/TrEMBL

Q3TJI3

Conserved Domains (3) summary

smart01052
Location:127 → 203

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:410 → 765

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 379

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531420.3 → XP_006531483.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

See identical proteins and their annotated locations for XP_006531483.1

UniProtKB/TrEMBL

A0A1B0GSE5, Q3TJI3

Conserved Domains (3) summary

smart01052
Location:127 → 203

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:407 → 762

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 375

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154328.1 → XP_036010221.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

UniProtKB/TrEMBL

A0A1B0GSE5, Q3TJI3

Conserved Domains (3) summary

smart01052
Location:127 → 203

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:407 → 762

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 375

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531416.5 → XP_006531479.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_006531479.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154330.1 → XP_036010223.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

Conserved Domains (3) summary

smart01052
Location:249 → 317

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:370 → 725

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 248

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154335.1 → XP_036010228.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X7

Conserved Domains (2) summary

smart01052
Location:10 → 64

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:185 → 540

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_030243809.1 → XP_030099669.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154333.1 → XP_036010226.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

Conserved Domains (3) summary

smart01052
Location:246 → 314

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:367 → 722

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:82 → 245

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_030243807.1 → XP_030099667.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531417.4 → XP_006531480.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_006531480.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154329.1 → XP_036010222.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X4

UniProtKB/TrEMBL

A0A1B0GSE5, Q3TJI3

Conserved Domains (3) summary

smart01052
Location:127 → 203

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:407 → 762

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 375

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_011248525.4 → XP_011246827.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_011246827.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531414.3 → XP_006531477.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_006531477.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_030243812.2 → XP_030099672.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_030243808.1 → XP_030099668.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531415.2 → XP_006531478.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_006531478.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_011248524.3 → XP_011246826.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_011246826.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154332.1 → XP_036010225.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X5

Conserved Domains (3) summary

smart01052
Location:249 → 317

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:370 → 725

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:85 → 248

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154334.1 → XP_036010227.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X6

Conserved Domains (3) summary

smart01052
Location:246 → 314

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:367 → 722

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:82 → 245

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_011248523.4 → XP_011246825.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_011246825.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_006531418.4 → XP_006531481.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

See identical proteins and their annotated locations for XP_006531481.1

UniProtKB/TrEMBL

Z4YJJ5

Conserved Domains (3) summary

smart01052
Location:471 → 539

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:592 → 947

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:307 → 470

CYLD_phos_site; Phosphorylation region of CYLD, unstructured
XM_036154327.1 → XP_036010220.1 ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

UniProtKB/Swiss-Prot

Q80TQ2, Q80VB3, Q8BXZ3, Q8BYL9, Q8CGB0

UniProtKB/TrEMBL

Q3V028

Conserved Domains (3) summary

smart01052
Location:468 → 536

CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network

cd02670
Location:589 → 944

Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam16607
Location:304 → 467

CYLD_phos_site; Phosphorylation region of CYLD, unstructured

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001128169.1: Suppressed sequence

Description

NM_001128169.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.