Mctp1 multiple C2 domains, transmembrane 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mctp1provided by MGI
Official Full Name: multiple C2 domains, transmembrane 1provided by MGI
Primary source: MGI:MGI:1926021
See related: Ensembl:ENSMUSG00000021596 AllianceGenome:MGI:1926021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810465F10Rik
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; negative regulation of response to oxidative stress; and regulation of neurotransmitter secretion. Predicted to be located in recycling endosome. Predicted to be active in synaptic vesicle membrane. Predicted to be integral component of membrane. Is expressed in brain. Orthologous to human MCTP1 (multiple C2 and transmembrane domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 5.3), ovary adult (RPKM 4.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.98 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (76530481..77181403)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (76382362..77033284)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that the Mctp1(dwnd) deletion affects the Nr2f1 gene located 1.4Mb away, downregulating transcription and protein expression in the embryonic cochlea. Remarkably, the Mctp1(dwnd) allele failed to complement a targeted inactivation allele of Nr2f1, and transheterozygotes or Mctp1(dwnd) homozygotes exhibit the same morphological defects observed in inner ears of Nr2f1 mutants
Title: A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

32.MMHAP83FRC11.seq (e-PCR)
- UniSTS:124003

RH127036 (e-PCR)
- UniSTS:209780

D13Mit97 (e-PCR), detects polymorphism
- UniSTS:127196

D13Mit99 (e-PCR), detects polymorphism
- UniSTS:127198

MHAa87e9.seq (e-PCR)
- UniSTS:125425

MHAa88g1.seq (e-PCR)
- UniSTS:125438

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multiple C2 and transmembrane domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001377108.1 → NP_001364037.1 multiple C2 and transmembrane domain-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC112671, AC124362, AC140345, AC161266

UniProtKB/TrEMBL

E9PW38

Conserved Domains (4) summary

cd04042
Location:40 → 161

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:203 → 318

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:358 → 476

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:619 → 680

PRT_C; Plant phosphoribosyltransferase C-terminal
NM_030174.3 → NP_084450.3 multiple C2 and transmembrane domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC112671, AC124362, AC140345, AC154788, AC161266

Consensus CDS

CCDS26656.1

UniProtKB/Swiss-Prot

E9PV86

Related

ENSMUSP00000118958.2, ENSMUST00000125209.9

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:423 → 538

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:578 → 696

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:839 → 924

PRT_C; Plant phosphoribosyltransferase C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

76530481..77181403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517462.4 → XP_006517525.3 multiple C2 and transmembrane domain-containing protein 1 isoform X1

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:459 → 574

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:614 → 732

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:875 → 960

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517466.4 → XP_006517529.3 multiple C2 and transmembrane domain-containing protein 1 isoform X4

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:459 → 574

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:614 → 732

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:875 → 936

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517464.4 → XP_006517527.3 multiple C2 and transmembrane domain-containing protein 1 isoform X3

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:439 → 554

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:594 → 712

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:855 → 940

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_036158226.1 → XP_036014119.1 multiple C2 and transmembrane domain-containing protein 1 isoform X6

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:439 → 554

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:594 → 712

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:855 → 916

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517463.4 → XP_006517526.3 multiple C2 and transmembrane domain-containing protein 1 isoform X2

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:443 → 558

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:598 → 716

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:859 → 944

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_036158227.1 → XP_036014120.1 multiple C2 and transmembrane domain-containing protein 1 isoform X7

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:423 → 538

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:578 → 696

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:839 → 900

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517467.4 → XP_006517530.3 multiple C2 and transmembrane domain-containing protein 1 isoform X5

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:410 → 525

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:565 → 683

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:826 → 911

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_017315643.2 → XP_017171132.1 multiple C2 and transmembrane domain-containing protein 1 isoform X8

Conserved Domains (4) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:410 → 525

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:565 → 683

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:826 → 887

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517472.4 → XP_006517535.3 multiple C2 and transmembrane domain-containing protein 1 isoform X14

Conserved Domains (3) summary

cd04042
Location:260 → 381

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:459 → 574

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cl14603
Location:614 → 633

C2; C2 domain
XM_006517468.5 → XP_006517531.1 multiple C2 and transmembrane domain-containing protein 1 isoform X9

UniProtKB/TrEMBL

E9PW38

Conserved Domains (4) summary

cd04042
Location:40 → 161

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:239 → 354

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:394 → 512

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:655 → 740

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517469.5 → XP_006517532.1 multiple C2 and transmembrane domain-containing protein 1 isoform X10

UniProtKB/TrEMBL

E9PW38

Conserved Domains (4) summary

cd04042
Location:40 → 161

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:223 → 338

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:378 → 496

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:639 → 724

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_030247469.2 → XP_030103329.1 multiple C2 and transmembrane domain-containing protein 1 isoform X11

UniProtKB/TrEMBL

E9PW38

Related

ENSMUSP00000105212.3, ENSMUST00000109583.9

Conserved Domains (4) summary

cd04042
Location:40 → 161

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:203 → 318

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:358 → 476

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:619 → 704

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517471.5 → XP_006517534.1 multiple C2 and transmembrane domain-containing protein 1 isoform X13

UniProtKB/TrEMBL

E9PW38

Conserved Domains (4) summary

cd04042
Location:40 → 161

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:190 → 305

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:345 → 463

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:606 → 691

PRT_C; Plant phosphoribosyltransferase C-terminal
XM_006517470.3 → XP_006517533.1 multiple C2 and transmembrane domain-containing protein 1 isoform X12

See identical proteins and their annotated locations for XP_006517533.1

UniProtKB/TrEMBL

E9PW38

Conserved Domains (4) summary

cd04042
Location:3 → 124

C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08376
Location:202 → 317

C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

cd08377
Location:357 → 475

C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)

pfam08372
Location:618 → 703

PRT_C; Plant phosphoribosyltransferase C-terminal