Birc7 baculoviral IAP repeat-containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Birc7provided by MGI
Official Full Name: baculoviral IAP repeat-containing 7provided by MGI
Primary source: MGI:MGI:2676458
See related: Ensembl:ENSMUSG00000038840 AllianceGenome:MGI:2676458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KIAP; Livin; ML-IAP; E130019N06
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Acts upstream of or within lens development in camera-type eye. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in eye; lens; lens fiber; and lens vesicle. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180570402..180575803)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180928609..180934010)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.
Title: Livin expression promotes keratinocyte release of inflammatory mediators in psoriasis.
Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses.
Title: Livin is protective in UVB-induced skin photodamage by regulating keratinocyte activation and inflammatory responses.
Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.
Title: Livin upregulation in keratinocytes of psoriasis patients to promote adhesion molecule expression.
The overexpression of PTEN concomitant with Livin gene silencing was confirmed as a feasible and effective in vitro and in vivo gene modulation method, which may represent a potential therapeutic strategy for the treatment of Gastric Cancer.
Title: Concomitant modulation of PTEN and Livin in gastric cancer treatment.
Data showed that Livin knock-down suppressed cell proliferation and inhibited cell invasion, accompanied by downregulation of VEGF and MMP-2/-9. Its silencing resulted in the prevention of xenograft tumor formation.
Title: Silencing of Livin inhibits tumorigenesis and metastasis via VEGF and MMPs pathway in lung cancer.
Birc7 is a late fiber gene of the mouse lens. Its expression in cells bordering the OFZ is consistent with a role in organelle degradation, a process in which the ubiquitin proteasome pathway has been implicated previously.
Title: Birc7: A Late Fiber Gene of the Crystalline Lens.
ML-IAP is dispensable for both normal mouse development and ocular homoeostasis.
Title: Characterization of ML-IAP protein stability and physiological role in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 7

Names: RING-type E3 ubiquitin transferase BIRC7

NP_001156719.1

EC 2.3.2.27

XP_006500728.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163247.1 → NP_001156719.1 baculoviral IAP repeat-containing protein 7 precursor

See identical proteins and their annotated locations for NP_001156719.1

Status: VALIDATED

Source sequence(s)

AL954707

Consensus CDS

CCDS50840.1

UniProtKB/Swiss-Prot

A0AUK9, A2AWP0

Related

ENSMUSP00000104503.2, ENSMUST00000108875.2

Conserved Domains (2) summary

cd00022
Location:94 → 161

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

pfam13920
Location:235 → 279

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

180570402..180575803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500665.3 → XP_006500728.1 baculoviral IAP repeat-containing protein 7 isoform X1

Conserved Domains (1) summary

cd00022
Location:94 → 161

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...