Ucn urocortin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ucnprovided by MGI
Official Full Name: urocortinprovided by MGI
Primary source: MGI:MGI:1276123
See related: Ensembl:ENSMUSG00000038676 AllianceGenome:MGI:1276123
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ucn1; Mpv17
Summary: This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]
Expression: Biased expression in heart adult (RPKM 1.5), frontal lobe adult (RPKM 0.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 17.11 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31295333..31296239, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31137989..31138895, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic deletion of Ucn1 reduced high levels of intake and preference across 2 weeks of continuous access drinking when alcohol concentrations were increased from 10 to 20 to 40%. Ucn1 deletion did not alter low-level drinking when the alcohol concentration remained at 10%.
Title: Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
Title: Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation.
it is shown that CRH and UCN upregulate galectin-1 expression in Ishikawa cell line and macrophages and this effect is mediated through CRHR1.
Title: Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation.
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
Title: Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum.
CNTF activates hypothalamic urocortin 1-expressing neurons both in vitro and in vivo.
Title: The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo.
The absence of the CB1 receptor alters the Ucn1 mRNA and peptide levels in Edinger-Westphal nucleus neurones, concomitant with an augmented stress response and increased anxiety-like behaviour.
Title: Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress.
EWcp-Ucn1 neurons play an important role in EtOH intake, preference, and reward.
Title: Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference.
CRF(1) agonists, Ucn 1 and stressin(1) -A, reduced feeding and induced interoceptive stress, whereas Ucn 2 potently suppressed feeding via a CRF(2) -dependent mechanism without eliciting malaise
Title: Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress.
Data suggest that UCN regulates osteoclast resorption by suppressing osteoclast maturation/function via suppression of constitutively active cation channel (CRFR2beta) with properties of canonical transient receptor potential 1 (TRPC1) channel.
Title: Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel.
Ucn1 gene was downregulated in 5-HTT KO and upregulated in 5-HTT TG mice which exhibit opposite changes in anxiety-related behavior; findings suggesti this peptide can be involved in behavioral changes observed in 5-HTT mutant mice
Title: Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor 1 binding	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in drinking behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of behavioral fear response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
NOT involved_in prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in response to auditory stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in response to immobilization stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
NOT involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IEA Inferred from Electronic Annotation more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urocortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346010.1 → NP_001332939.1 urocortin preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC109608, BC144891

Consensus CDS

CCDS19174.1

UniProtKB/Swiss-Prot

O88390, P81615, Q14A76

Related

ENSMUSP00000144390.2, ENSMUST00000201184.2

Conserved Domains (1) summary

pfam00473
Location:83 → 120

CRF; Corticotropin-releasing factor family
NM_021290.2 → NP_067265.1 urocortin preproprotein

See identical proteins and their annotated locations for NP_067265.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC109608

Consensus CDS

CCDS19174.1

UniProtKB/Swiss-Prot

O88390, P81615, Q14A76

Related

ENSMUSP00000035321.3, ENSMUST00000043475.7

Conserved Domains (1) summary

pfam00473
Location:83 → 120

CRF; Corticotropin-releasing factor family