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    Cnnm2 cyclin M2 [ Mus musculus (house mouse) ]

    Gene ID: 94219, updated on 12-May-2024

    Summary

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    Official Symbol
    Cnnm2provided by MGI
    Official Full Name
    cyclin M2provided by MGI
    Primary source
    MGI:MGI:2151054
    See related
    Ensembl:ENSMUSG00000064105 AllianceGenome:MGI:2151054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clp2; Acdp2
    Summary
    Enables ATP binding activity and magnesium ion transmembrane transporter activity. Acts upstream of or within magnesium ion transport. Located in basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and retina. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.0), adrenal adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnnm2 in Genome Data Viewer
    Location:
    19 C3; 19 38.97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46745273..46867019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46756834..46878580)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene arsenite methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E8753 Neighboring gene STARR-seq mESC enhancer starr_46325 Neighboring gene STARR-seq mESC enhancer starr_46328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46962419-46962620 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene DBF4 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47044836-47045019 Neighboring gene STARR-seq mESC enhancer starr_46332 Neighboring gene lysophosphatidic acid receptor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation. Yamazaki D, et al. Biochem Biophys Res Commun, 2016 Jun 3. PMID 27150626
    2. Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter. Goytain A, et al. Physiol Genomics, 2005 Aug 11. PMID 15899945
    3. Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure. Funato Y, et al. Nat Commun, 2021 Jun 17. PMID 34140503, Free PMC Article
    4. Renal function of cyclin M2 Mg2+ transporter maintains blood pressure. Funato Y, et al. J Hypertens, 2017 Mar. PMID 28033128
    5. Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. Hirata Y, et al. J Biol Chem, 2014 May 23. PMID 24706765, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.
      Title: Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.
    2. we generated kidney-specific Cnnm2- deficient mice and clearly demonstrated that the CNNM2 function in the kidney is important in maintaining not only magnesium homeostasis but also blood pressure.
      Title: Renal function of cyclin M2 Mg2+ transporter maintains blood pressure.
    3. data shed new light on the structural basis underlying the interaction between PRL phosphatases and CNNM transporters and provides a hypothesis about the molecular mechanism by which PRL-1, upon binding to CNNM2, might increase the intracellular concentration of Mg(2+) thereby contributing to tumor progression and metastasis.
      Title: Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
    4. Thus, sperm motility and Ca(2+) response were more severely affected in sperm from Cnnm2(+/Delta); Cnnm4(Delta/Delta) mice than in those from Cnnm4(Delta/Delta) mice, implicating CNNM2 in regulating these processes.
      Title: Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation.
    5. analysis of structure of CNNM2 and its post-translational modifications
      Title: Membrane topology and intracellular processing of cyclin M2 (CNNM2).
    6. ACDP2 may provide a regulated transporter for Mg2+ and other divalent cations in epithelial ce
      Title: Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metal transporter CNNM2
    Names
    ancient conserved domain protein 2
    ancient conserved domain-containing protein 2
    cyclin-like protein 2
    mACDP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102471.1 → NP_001095941.1  metal transporter CNNM2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF216961, AK159616, BC052513
      Consensus CDS
      CCDS50460.1
      UniProtKB/Swiss-Prot
      Q3TWN3
      Related
      ENSMUSP00000076850.5, ENSMUST00000077666.6
      Conserved Domains (2) summary
      cd04590
      Location:470 → 575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257 → 431
      DUF21; Domain of unknown function DUF21

    2. NM_033569.3 → NP_291047.2  metal transporter CNNM2 isoform a

      See identical proteins and their annotated locations for NP_291047.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF216961, AK159616, BC052513
      Consensus CDS
      CCDS50459.1
      UniProtKB/Swiss-Prot
      A0PJF1, E9PUH1, Q3TWN3, Q7TT07, Q8C8V4, Q9JIM8
      Related
      ENSMUSP00000096972.5, ENSMUST00000099373.12
      Conserved Domains (2) summary
      cd04590
      Location:470 → 575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257 → 431
      DUF21; Domain of unknown function DUF21

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      46745273..46867019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527490.4 → XP_006527553.1  metal transporter CNNM2 isoform X1

      Conserved Domains (1) summary
      COG1253
      Location:256 → 540
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

    RNA

    1. XR_004940188.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TWN3.3 GenPept UniProtKB/Swiss-Prot:Q3TWN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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